Effects of the common 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness to recombinant follicle-stimulating hormone

American Journal of Reproductive Immunology : AJRI
C J ThalerP Lohse

Abstract

The common 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene is less prevalent in mothers of spontaneously conceived dichorionic twins than in those with singleton pregnancies. (Hasbargen U, Lohse P, Thaler CJ: Hum Reprod 2000; 15:2659-2662). As polyovulation is a pre-requisite for dichorionic pregnancies, we investigated whether the T allele is associated with reduced ovarian responsiveness to follicle-stimulating hormone (FSH). We studied 105 infertility patients undergoing a total of 269 A.R.T cycles stimulated with recombinant (r)-FSH. The MTHFR 677C>T genotype was analyzed by digestion of polymerase chain reaction-amplified DNA fragments. Homozygous 677C patients older than 35, required significantly (P <0.02) less r-FSH and produced significantly more oocytes (P < 0.04) and higher maximal serum estradiol concentrations (P < 0.002) than heterozygous or homozygous carriers of the 677T allele. Our results suggest that, in patients of advanced reproductive age, the MTHFR 677C>T mutation affects ovarian responsiveness.

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Citations

Mar 13, 2012·Journal of Assisted Reproduction and Genetics·Amanda Souza SettiEdson Borges
Aug 25, 2011·Human Reproduction Update·S AltmäeA Salumets
May 6, 2010·BMC Developmental Biology·Misa U AustinCraig W LaMunyon
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Jun 5, 2014·Pharmacogenomics·Belen LledoRafael Bernabeu
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Dec 3, 2020·Antioxidants·Cristina Rodríguez-Varela, Elena Labarta
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May 4, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Parnaz Borjian BoroujeniAnahita Mohseni Meybodi
May 26, 2021·Journal of Assisted Reproduction and Genetics·Xinrui WangXin Feng
May 30, 2021·Journal of Assisted Reproduction and Genetics·Sayyed Mohammad Hossein GhaderianSaghar Salehpour

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