Effects of the composition of peritoneal dialysis fluid on chemiluminescence, phagocytosis, and bactericidal activity in vitro.

Infection and Immunity
A K DuweJ W Weatherhead

Abstract

Commercial fluid used for peritoneal lavage in peritonitis and in peritoneal dialysis suppressed the activity of peripheral blood leukocytes as measured by chemiluminescence, phagocytosis, and bacterial killing. Suppression was found to be due to the low pH and high osmolality of the fluid. The pH was adjusted to noninhibitory levels in vivo within 30 min, whereas osmolality changes were less rapid and remained at inhibitory levels for fluids of high dextrose concentration (4.25%). Chemiluminescence was the most sensitive assay for inhibitory effects of pH and osmolality, as well as for urea and heparin. The metabolic waste product urea at levels normally found in dialysate and heparin at concentrations routinely added to fluid inhibited only chemiluminescence, whereas creatinine and added insulin were not inhibitory. High fluid volume also resulted in a decrease in efficiency of bacterial killing. These results suggest some changes to be made in the treatment of peritonitis and in peritoneal dialysis.

References

May 1, 1978·Infection and Immunity·A M HookeJ A Bellanti
Oct 1, 1979·Current Problems in Surgery·T HauR L Simmons
Mar 8, 1976·Biochemical and Biophysical Research Communications·R C Allen, L D Loose
Jan 1, 1968·Medicine·J Z MontgomerieL B Guze
Jan 1, 1980·The Journal of Infectious Diseases·A G BarbourH R Hill

❮ Previous
Next ❯

Citations

Jan 1, 1984·Scandinavian Journal of Infectious Diseases·N GrefbergP Nilsson
Nov 30, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M TuncerF F Ersoy
Nov 20, 2002·Seminars in Dialysis·J Passlick-DeetjenH Schilling
Nov 20, 2002·Seminars in Dialysis·Reinhard R Brunkhorst
May 8, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Ryouji OgataMasanori Kitamura
May 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hisashi JohnoMasanori Kitamura
Nov 5, 1988·BMJ : British Medical Journal·D C PagniezA Tacquet
Dec 8, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S Q Lew, K Kaveh
Mar 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D L GordonV M Avery
Jan 1, 1984·Scandinavian Journal of Urology and Nephrology·K HuttunenA Tiilikainen
Jun 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A M NeuH M Lederman
Oct 27, 2001·Seminars in Dialysis·J Passlick-DeetjenA Jörres
Oct 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron
Sep 1, 2005·Nephron. Experimental Nephrology·Siska MortierAn De Vriese
Mar 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P C Taylor
Jan 28, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·John R HotchkissPhilip S Crooke
Jul 13, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Rafia I ChaudhryThomas A Golper
Jun 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H van BronswijkJ Verhoef
May 5, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Charles J Diskin
Mar 30, 2017·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Karima FarhatFrans J van Ittersum
Feb 24, 2018·Artificial Organs·Masanao IwamotoTakashi Horiuchi
May 1, 2000·Alternatives to Laboratory Animals : ATLA·H NygrenN Yahyapour
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Marina Penélope CatalanAlberto Ortiz
Mar 22, 2001·Kidney International·S JonesUNKNOWN Bicarbonate/Lactate Study Group
Sep 5, 2001·Advances in Renal Replacement Therapy·A Jörres
Aug 1, 1984·Journal of Clinical Microbiology·H A VerbrughP K Peterson
Nov 1, 1996·Clinical and Diagnostic Laboratory Immunology·I DanielsJ Fletcher
Jul 1, 1986·Journal of Clinical Microbiology·W A McDonaldM I Bowmer
Aug 1, 1987·Journal of Clinical Microbiology·D M HarveyJ Fletcher
Jan 1, 1992·Clinical Microbiology Reviews·A von Graevenitz, D Amsterdam
Feb 12, 2004·Kidney International. Supplement·John D WilliamsUNKNOWN Biopsy Registry Study Group
Feb 12, 2004·Kidney International. Supplement·Clifford J Holmes, Dirk Faict
Feb 12, 2004·Kidney International. Supplement·Catherine M Hoff
Feb 6, 1998·The Journal of Laboratory and Clinical Medicine·R KohanL Gotloib

❮ Previous
Next ❯

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