Effects of the deregulated expression of human interleukin-2 in transgenic mice

International Immunology
Y IshidaT Honjo

Abstract

We constructed transgenic mice that carry the cDNA of human interleukin-2 (IL-2) under the control of the H-2Kd promoter. The IL-2 transgenic mice expressed human IL-2 mRNA in the thymus, spleen, bone marrow, lung, muscle and skin. Human IL-2 protein was also detected in their sera. The IL-2 transgenic mice suffered from alopecia and pneumonia, but no typical autoimmune reactions seemed to be involved in these lesions. In the epidermis of the IL-2 transgenic mice there was an increase in Thy-1+ dendritic epidermal cells (DEC), which might be involved in the skin lesion. Immune responses of their spleen cells against antigens were significantly impaired whereas their spleen cells responded well to polyclonal lymphocyte activators.

Citations

Jan 1, 1993·Archives of Dermatological Research·M AkiyamaT Nishikawa
Jun 1, 1995·Cancer Metastasis Reviews·K Brown, A Balmain
Jun 1, 1991·Current Opinion in Immunology·S L Swain
Aug 31, 2013·Cytokine·Changwan HongJung-Hyun Park
Mar 20, 2002·Cytokine & Growth Factor Reviews·Todd A FehnigerMichael A Caligiuri
Feb 1, 1993·The Journal of Experimental Medicine·B E RichP Leder
Mar 3, 2011·The Journal of Clinical Investigation·Jianhua YuMichael A Caligiuri
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J Marks-KonczalikY Tagaya
Apr 21, 1997·The Journal of Experimental Medicine·Y HigashiH Kondoh
Aug 1, 1991·The British Journal of Dermatology·N ShibagakiS Shimada
Aug 18, 2005·The Journal of Biological Chemistry·Hakju KwonWarner C Greene
Jan 3, 2001·Blood·T A Fehniger, M A Caligiuri
Jun 1, 1990·European Journal of Immunology·S S BurtlesD C Hooper
Jul 1, 1995·The Journal of Investigative Dermatology·R E Tigelaar, J M Lewis

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