Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats

Environmental Health Perspectives
Krittika KrishnanAndrea C Gore

Abstract

Exposure to endocrine-disrupting chemicals (EDCs) during gestation influences development of the F1 generation offspring and can result in disease and dysfunction in adulthood. Limited evidence suggests consequences on the F2 generation, exposed as germ cells within the F1 fetus. These F2s provide a unique window into the programming effects of EDCs. This study assessed intergenerational effects of EDC exposure on adult physiology and behavior in Sprague-Dawley rats. Pregnant rats were exposed to either a polychlorinated biphenyl (PCB) mixture, Aroclor 1,221 (A1221), the fungicide vinclozolin (VIN), or the vehicle (VEH) (6% dimethylsulfoxide in sesame oil) alone. A1221 is weakly estrogenic, while VIN is antiandrogenic, enabling us to compare different classes of EDCs. The F1 male and female offspring were bred to generate the paternal- and maternal-lineage F2 generation. This F2 generation was assessed for physiological outcomes, ultrasonic vocalizations (USVs), and sexual behavior in adulthood. Each EDC caused phenotypic effects in a sex- and lineage-dependent manner. The most robustly affected group was the paternal-lineage males. F2 VIN paternal male descendants had increased body weight throughout the lifespan, lower concen...Continue Reading

References

Nov 1, 1986·Archives of Environmental Contamination and Toxicology·Y TakagiT Kitaura
Dec 1, 1969·Journal of Comparative and Physiological Psychology·N T Adler
Jan 18, 1980·Science·I L Ward, J Weisz
Nov 1, 1994·Journal of Reproduction and Fertility·C Coopersmith, M S Erskine
Dec 1, 1993·Hormones and Behavior·G S Benedict, C L Williams
Apr 7, 1998·Journal of Comparative Psychology·B KnutsonJ Panksepp
Dec 20, 1999·Behavioural Brain Research·R G Paredes, B Vazquez
Oct 13, 2000·Regulatory Toxicology and Pharmacology : RTP·J HellwigC Gembardt
Aug 11, 2001·Science·W ReikJ Walter
Nov 22, 2001·Hormones and Behavior·I Martínez, R G Paredes
Apr 16, 2003·Hormones and Behavior·Shannon M Harding, Marilyn Y McGinnis
Jul 22, 2004·Behavioural Brain Research·Mary S ErskineEva K Polston
Jun 4, 2005·Science·Matthew D AnwayMichael K Skinner
Jun 17, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Retha R NewboldWendy N Jefferson
Feb 6, 2007·Hormones and Behavior·Rebecca M SteinbergAndrea C Gore
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·David CrewsMichael K Skinner
Dec 21, 2007·The European Journal of Neuroscience·Blanca PiedrafitaVicente Felipo
Jan 15, 2008·Physiology & Behavior·Markus WöhrBerry Spruijt
Feb 22, 2008·Environmental Health Perspectives·Edward F FitzgeraldHeraline E Hicks
Aug 16, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Adolfo Sierra-SantoyoMichael F Hughes
Jul 17, 2010·Hormones and Behavior·David Crews
Aug 7, 2010·Journal of Visualized Experiments : JoVE·Esther Y MaierChristine L Duvauchelle
Dec 15, 2010·Neuroscience and Biobehavioral Reviews·Jeffrey BurgdorfJoseph R Moskal
May 17, 2011·Environmental Health Perspectives·David Crews, Andrea C Gore
Oct 25, 2011·Trends in Genetics : TIG·Sébastien A Smallwood, Gavin Kelsey
Mar 1, 2012·Frontiers in Neuroscience·Kathryn M LenzMargaret M McCarthy
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·David CrewsMichael K Skinner
Jun 19, 2012·Endocrinology·Jennifer T WolstenholmeJessica J Connelly
Feb 5, 2013·Current Opinion in Neurobiology·Stefan M Brudzynski
Jul 9, 2013·Journal of Neuroscience Methods·James M RenoChristine L Duvauchelle

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Citations

Mar 21, 2019·Environmental and Molecular Mutagenesis·Jill Escher, Suzanne Robotti
Oct 17, 2019·International Journal of Environmental Research and Public Health·Sarah Lyon-CaenThe Sepages Study Group
Jul 22, 2020·Endocrinology·Morgan E Hernandez ScudderAndrea C Gore
Jul 22, 2020·Current Opinion in Pediatrics·Lorenzo IughettiSergio Bernasconi
Aug 17, 2020·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Morgan E Hernandez ScudderAndrea C Gore
Jul 27, 2020·Environmental Epigenetics·Jill Escher, La Donna Ford
Mar 21, 2021·Developmental Biology·Nelson R Cabej
Nov 26, 2019·Molecular and Cellular Endocrinology·Sakina Mhaouty-Kodja
May 1, 2021·Journal of the Endocrine Society·Morgan E Hernandez ScudderAndrea C Gore
May 1, 2021·Brain Sciences·Charles LenellMichelle R Ciucci
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anne LoronVéronique Coma
Oct 2, 2021·Journal of Autism and Developmental Disorders·Jill EscherVictor G Corces

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Methods Mentioned

BETA
Chemical Treatment
PCAs
PCA

Software Mentioned

WAV
WAAVES
UltraSoundGate
file Automated Analysis of Vocalizations Environment Specific ...
Avisoft

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