PMID: 9299214May 1, 1997Paper

Effects of the estrous cycle and the gender differences on hepatic drug-metabolising enzyme activities

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
M WatanabeS Kobayashi

Abstract

The aim of the present study was to investigate the effects of the estrous cycle and physiological dose of estradiol (E2) and the gender difference on several hepatic drug-metabolising enzyme activities. Eight-week old female Sprague-Dawley rats at different stages of the estrous cycle [proestrous (P), estrous (E), and diestrous (D)] and 8-week old male rats were used in this study (n = 5, respectively). Serum E2 level at D was higher than that at E and lower than that at P. The hepatic cytochrome P450 content, aniline hydroxylase, ethoxycoumarin O-deethylase and aminopyrine N-demethylase activities in male were significantly higher than those in female at any stage of the estrous cycle and these activities in female remained unchanged during the estrous cycle. Neither the estrous cycle nor the gender difference affected the cytochrome b5 content. NADPH-cytochrome c reductase (fPT) activity at P was similar to that in male, and was significantly higher than that in E and D. fPT activity was increased by the administration of physiological dose of E2 in ovariectomized rats. Uridine diphosphate glucuronyltransferase (UDP-GT) activity at E was significantly lower than that at P or D and that activity in female was significantly lo...Continue Reading

References

Apr 1, 1978·Analytical Biochemistry·A Aitio
Jan 1, 1992·European Journal of Clinical Pharmacology·J D LaneC M Kuhn
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H A el SheikhH J Hapke
Jan 1, 1990·European Journal of Clinical Pharmacology·B BruguerolleH Razzouk
Jan 1, 1988·Acta Anatomica·G S Montes, E H Luque
Jul 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T P Gibson
Dec 1, 1968·Japanese Journal of Pharmacology·R KatoM Takayanagi
Sep 1, 1971·American Journal of Obstetrics and Gynecology·D R MishellI H Thorneycroft
Nov 1, 1983·British Journal of Clinical Pharmacology·J O MinersD J Birkett
Jan 1, 1981·Methods in Enzymology·B Burchell, P Weatherill
Sep 1, 1982·British Journal of Clinical Pharmacology·K WilsonD Burnett
Sep 1, 1981·European Journal of Biochemistry·P KremersJ E Gielen
Aug 1, 1980·Chemico-biological Interactions·W VizethumG Goerz
May 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E C Pirog, D C Collins
Oct 1, 1993·Clinical Pharmacology and Therapeutics·K H LewW J Jusko

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Citations

Jul 1, 2011·Archives of Toxicology·Sang Yoon LeeSang Kyum Kim
Jun 12, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Matthew B SchabathXifeng Wu
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·J PodhornaR E Brown
Mar 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·E P WalaX Jing
Nov 30, 2016·Toxicologic Pathology·Michael Gochfeld
Aug 9, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rhonda L StelckLaura S Van Winkle
Feb 1, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mohammed A KhayumJanine Doorduin

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