Effects of the estrous cycle, pregnancy, and interferon tau on 2',5'-oligoadenylate synthetase expression in the ovine uterus.

Biology of Reproduction
G A JohnsonT E Spencer

Abstract

The enzymes which comprise the 2',5'-oligoadenylate synthetase (OAS) family are interferon (IFN) stimulated genes which regulate ribonuclease L antiviral responses and may play additional roles in control of cellular growth and differentiation. This study characterized OAS expression in the endometrium of cyclic and pregnant ewes as well as determined effects of IFNtau and progesterone on OAS expression in cyclic or ovariectomized ewes and in endometrial epithelial and stromal cell lines. In cyclic ewes, low levels of OAS protein were detected in the endometrial stroma (S) and glandular epithelium (GE). In early pregnant ewes, OAS expression increased in the S and GE on Day 15. OAS expression in the lumenal epithelium (LE) was not detected in uteri from either cyclic or pregnant ewes. Intrauterine administration of IFNtau stimulated OAS expression in the S and GE, and this effect of IFNtau was dependent on progesterone. Ovine endometrial LE, GE, and S cell lines responded to IFNtau with induction of OAS proteins. In all three cell lines, the 40/46-kDa OAS forms were induced by IFNtau, whereas the 100-kDa OAS form appeared to be constitutively expressed and not affected by IFNtau. The 69/71-kDa OAS forms were induced by IFNtau i...Continue Reading

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Citations

May 3, 2013·Protein & Cell·Lei XuWenjun Liu
Jan 22, 2003·Animal Reproduction Science·S Schäfer-Somi
Aug 24, 2002·Biology of Reproduction·Cheryl S RosenfeldR Michael Roberts
Feb 20, 2004·Biology of Reproduction·Thomas E SpencerFuller W Bazer
Jul 9, 2004·Reproductive Biology and Endocrinology : RB&E·Thomas E Spencer, Fuller W Bazer
Oct 12, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Gwonhwa SongFuller W Bazer
Feb 2, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Thomas E SpencerEckhard Wolf
Jan 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Gwonhwa SongThomas E Spencer
Jul 21, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Yizhen ChenR Michael Roberts
Aug 24, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Thomas E SpencerPatrick Lonergan
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·C Allison GrayThomas E Spencer
Nov 12, 2010·Domestic Animal Endocrinology·G SongF W Bazer
Apr 5, 2013·Reproduction in Domestic Animals = Zuchthygiene·X-L WangS-M Zeng
Jul 24, 2004·Animal Reproduction Science·T E SpencerF W Bazer
Jan 21, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Irene Ruiz-GonzálezFuller W Bazer
Jan 24, 2002·Biology of Reproduction·M David StewartThomas E Spencer
Jan 1, 2016·Reproduction, Fertility, and Development·T E SpencerP Lonergan
Oct 7, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Thomas R HansenThomas E Spencer
Sep 6, 2018·Annual Review of Animal Biosciences·Thomas E SpencerFrank F Bartol
Mar 25, 2006·Endocrinology·Gwonhwa SongFuller W Bazer
Oct 4, 2019·Scientific Reports·Jin-Wei XinJin-Cheng Zhong
Jul 31, 2003·Reproduction in Domestic Animals = Zuchthygiene·E WolfF Sinowatz
Jan 1, 2010·Biology of Reproduction·Rebecca C BottThomas R Hansen
Jan 7, 2003·In Vitro Cellular & Developmental Biology. Animal·S WoldesenbetG R Newton

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BETA
electrophoresis

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Statistical Analysis System
Adobe Photoshop

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