Effects of the Ethyl Acetate Fraction of Alchornea triplinervia on Healing Gastric Ulcer in Rats

Pharmaceuticals
Zeila Pinheiro LimaClélia Akiko Hiruma-Lima

Abstract

Alchornea triplinervia (Spreng.) Muell. Arg (Euphorbiaceae) is a medicinal plant commonly used by people living in the Cerrado region of Brazil to treat gastrointestinal ulcers. We previously described the gastroprotective action of methanolic extract (ME) of Alchornea triplinervia and the ethyl acetate fraction (EAF) in increasing of prostaglandin E₂ (PGE₂) gastric levels in the mucosa. In this work we evaluated the effect of EAF in promoting the healing process in rats with acetic acid-induced gastric ulcers. In addition, toxicity was investigated during treatment with EAF. After 14 days of treatment with EAF, the potent stimulator of gastric cell proliferation contributed to the acceleration of gastric ulcer healing. Upon immunohistochemical analysis, we observed a pronounced expression of COX-2, mainly in the submucosal layer. The 14-day EAF treatment also significantly increased the number of neutrophils in the gastric mucosa regeneration area. The EAF induced angiogenesis on gastric mucosa, observed as an increase of the number of blood vessels supplying the stomach in rats treated with EAF. Oral administration for 14 days of the ethyl acetate fraction from Alchornea triplinervia accelerated the healing of gastric ulcers ...Continue Reading

References

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Citations

Nov 29, 2014·Pharmaceutical Biology·Maliheh SafaviAlireza Foroumadi
Jun 11, 2015·Anais Da Academia Brasileira De Ciências·Luciana M R AntinarelliElaine S Coimbra
Jan 21, 2017·BMC Veterinary Research·Nahla Saeed Al-WajeehMahmood Ameen Abdulla
Feb 13, 2021·Scientific Reports·Enrico GugliandoloRosalia Crupi

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