Effects of the glucocorticoid agonist, RU28362, and the antagonist RU486 on lung phosphatidylcholine and antioxidant enzyme development in the genetically obese Zucker rat

Biochemical Pharmacology
S C LangleyD A York

Abstract

The biochemical maturation of the lung in late gestation and in the young animal is regulated by glucocorticoids. The present study was aimed at dissociating the different glucocorticoid receptor sites involved in these regulatory functions. The obese Zucker rat was selected as a model for this study as it exhibits hypersensitivity to glucocorticoid hormone action by virtue of its elevated receptor numbers and activity. Two synthetic steroid analogues were administered to obese animals; RU28362, a specific type II receptor agonist, and the type II antagonist RU486. RU28362 promoted a strong catabolic effect, which was associated with reduced food intake and the abolition of growth in the rats. The agonist, RU28362, attenuated developmental increases in antioxidant enzyme activities, and altered the growth of the tissue. At the age studied, development of the lung phosphatidylcholine (PC) system was almost complete, but RU28362 increased disaturated PC 16:0/16:0 concentrations by almost 2-fold, and altered the molecular composition of total pulmonary PC. RU486 attenuated the growth of the rats and reduced their food intake. Treatment with the type II antagonist attenuated lung growth and increased the activities of pulmonary cop...Continue Reading

References

May 6, 1975·European Journal of Biochemistry·S Diamant, E Shafrir
Jan 1, 1991·The International Journal of Biochemistry·F J KellyT D Postle
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B L Scott, N G Bazan
Mar 1, 1989·Experimental Lung Research·N GuettariC Tordet
Jan 1, 1989·Life Sciences·L DevenportT Thomas
Mar 1, 1971·Journal of Applied Physiology·N S WangW M Thurlbeck
Jan 1, 1974·Pharmacology, Biochemistry, and Behavior·C W SimpsonG Wolf
Mar 1, 1971·Journal of Applied Physiology·R V Kotas, M E Avery
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B T Smith, K Sabry
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

❮ Previous
Next ❯

Citations

Sep 1, 1990·Physiology & Behavior·M E BlighT W Castonguay
Aug 1, 1997·Molecular Aspects of Medicine·E Jéquir, L Tappy
Apr 30, 1999·Physiological Reviews·E Jéquier, L Tappy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.