Effects of the hypnotic drug zolpidem on cell proliferation and survival in the dentate gyrus of young and old rats

Brain Research
Luiz F TakaseBarry L Jacobs

Abstract

Sleep loss/disruption has been shown to suppress adult hippocampal neurogenesis. Whether the administration of hypnotic drugs, by promoting sleep, especially in older subjects, who typically exhibit poor sleep, has a beneficial effect on neurogenesis parameters is unknown. We examined the effects of zolpidem, a widely prescribed nonbenzodiazepine hypnotic, on cell proliferation and survival in the dentate gyrus of young ( approximately 2 1/2 months) and old ( approximately 13 months) male Sprague-Dawley rats. Zolpidem (5, 10 or 20 mg/kg, i.p.) or vehicle was administered twice daily, at the beginning and middle of the sleep period, for either 2 days (acute study) or 21 days (chronic study). Proliferation and cell survival were measured by staining for Ki67 or 5-bromo-2'-deoxyurdine (BrdU), respectively. Acute administration of zolpidem produced a suppression of cell proliferation, which attained statistical significance only in the aged animals. The magnitude of the suppressive effect was larger in the hilus than in the subgranular zone (SGZ). In contrast, chronic administration of zolpidem produced little or no effect on proliferation in either age group, despite marked differences in basal proliferation levels between the two...Continue Reading

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Citations

Apr 7, 2011·The Journal of Veterinary Medical Science·Sung Min NamYeo Sung Yoon
Apr 23, 2010·Journal of Sleep Research·Melvi MethipparaDennis McGinty
Sep 25, 2009·The International Journal of Neuropsychopharmacology·Xiaowei W SuRonald S Duman
Oct 28, 2017·Frontiers in Neural Circuits·Cristina Navarro-SanchisSandrine Thuret

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