Effects of the immunomodulating agent R837 on acute and latent herpes simplex virus type 2 infections.

Antimicrobial Agents and Chemotherapy
D I Bernstein, C J Harrison

Abstract

R837 is an immune modulator with no in vitro activity against herpes simplex virus (HSV). We evaluated topical R837 as therapy for genital HSV type 2 infection using the guinea pig model of this disease. Furthermore, we investigated the effect of R837 therapy on acute and latent neural HSV infections. Therapy initiated 12 h after viral inoculation and given twice a day significantly reduced the acute neural infection so that HSV was recovered from only 1 of 64 neural tissue specimens obtained from R837 recipients compared with 43 of 56 specimens obtained from placebo recipients (P less than 0.0001). R837 initiated 36 h after HSV inoculation and given once a day also significantly reduced the total mean lesion score of the acute disease from 14.1 +/- 4.3 to 2.6 +/- 5.3 (P less than 0.0001) and shortened the period of vaginal HSV shedding from 6.9 +/- 1.7 to 3.2 +/- 1.4 days (P less than 0.001). R837-treated animals also developed fewer HSV recurrences than did controls (2.0 +/- 1.7 versus 5.1 +/- 1.7; P less than 0.0002). Latent HSV was detected in 23 of 24 dorsal root ganglia explant cultures from placebo recipients but in only 2 of 30 cultures from R837-treated animals, and HSV in these 2 cultures was detectable only with the ...Continue Reading

References

May 1, 1979·Antimicrobial Agents and Chemotherapy·R J KleinE DeStefano
Apr 1, 1979·Antimicrobial Agents and Chemotherapy·H J FieldP Wildy
May 1, 1988·Antimicrobial Agents and Chemotherapy·M ChenG D Hsiung
Sep 1, 1986·The Journal of General Virology·D I Bernstein, L R Stanberry
Sep 1, 1987·The Journal of Infectious Diseases·D I BernsteinM G Myers
Jul 1, 1987·Antimicrobial Agents and Chemotherapy·L J EronP I Nadler
Sep 1, 1986·The Journal of Infectious Diseases·T L KuhlsY J Bryson
Oct 1, 1986·Antimicrobial Agents and Chemotherapy·L J EronD Santomauro
Sep 7, 1984·JAMA : the Journal of the American Medical Association·G J MertzD L Tyrrell
Sep 1, 1982·The Journal of Infectious Diseases·L R StanberryJ C Overall

❮ Previous
Next ❯

Citations

Nov 1, 1995·Antiviral Research·M A TomaiJ F Gerster
Mar 16, 2000·Developmental and Comparative Immunology·S Rautenschlein, J M Sharma
Dec 10, 1999·Antiviral Research·R L MillerJ F Gerster
Jul 20, 1999·International Journal of Immunopharmacology·R L MillerM A Tomai
Feb 15, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·J M Kirwan, C S Herrington
Dec 5, 2002·Clinical and Experimental Dermatology·M A Stanley
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Se-Jeong KimSang-Kyou Han
Jun 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S J GibsonM A Tomai
Apr 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K KaracaR L Miller
Jan 25, 2005·International Journal of Dermatology·Slawomir MajewskiStefania Jablonska
Nov 15, 1996·European Journal of Biochemistry·G H Werner, P Jollès
Aug 14, 1998·Infectious Diseases in Obstetrics and Gynecology·H W Buck
Nov 25, 2003·Infectious Diseases in Obstetrics and Gynecology·Kyle H RamseyKevin A Ault
Oct 13, 2007·Expert Review of Vaccines·Mark A TomaiJohn P Vasilakos
Jul 5, 2005·Expert Opinion on Investigational Drugs·H B SladeR L Miller
Nov 26, 2010·Dermatologic Clinics·Ron Birnbaum, Noah Craft
Dec 7, 2007·Antiviral Research·Heather GreenstoneCatherine Laughlin
Dec 21, 2004·The British Journal of Dermatology·B LysaM Walz
Mar 5, 1998·Journal of the American Academy of Dermatology·K R BeutnerJ M Douglas
Oct 22, 2002·The Journal of General Virology·Nigel BourneLawrence R Stanberry
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R P BurnsA A Gaspari
Nov 20, 2012·Oncoimmunology·Erika VacchelliGuido Kroemer
Nov 10, 2006·Infectious Diseases in Obstetrics and Gynecology·Joseph M LyonsServaas A Morré
May 24, 2016·Immunology·Tom Y-H Wu
Dec 3, 2003·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Christoffer Ingves, Gregor B E Jemec
Jul 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·H FujisawaD N Sauder
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·K R BeutnerK A Schmitt
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G A BishopM A Tomai
Apr 3, 2001·Journal of Cutaneous Medicine and Surgery·J SeversonS K Tyring
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christie L DoxseeRoss M Kedl
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Smita NairEli Gilboa
Jun 22, 2000·Journal of the American Academy of Dermatology·S K Tyring
Jul 1, 1994·Clinical Microbiology Reviews·A G Johnson

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