PMID: 9442287Jan 27, 1998Paper

Effects of the in vitro chemical environment during early embryogenesis on subsequent development

Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement
D Rieger

Abstract

The development of the preimplantation embryo seems morphologically very simple, and embryologists previously assumed that an embryo that developed to the blastocyst stage was fully capable of normal development after transfer to the uterus of a recipient female. This complacency was disturbed by reports that exposure of early embryos to mutagens such as methylnitrosourea led to fetal abnormalities, decreased birth rates, and decreased life-span. Even more disturbing are recent reports that culture of early embryos in supposedly benign conditions can adversely affect their subsequent development. Techniques have been developed for the production of cattle and sheep embryos by in-vitro fertilization and by cloning. Such embryos must be cultured for several days before they can be transferred, and, in some cases, this has been related to abortion, very high birthweight, physical abnormalities and peri-natal mortality of the calves and lambs. This syndrome may result from an unbalanced development of the trophoblast relative to the inner-cell mass, possibly related to the presence of serum, glucose, or ammonium in the culture medium. An analogous phenomenon has been observed in human in-vitro fertilization where babies from single...Continue Reading

Citations

Apr 18, 2001·Reproduction in Domestic Animals = Zuchthygiene·K J Betteridge
Jan 1, 2013·Annual Review of Animal Biosciences·Rebecca L Krisher

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