Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers

The Journal of Clinical Endocrinology and Metabolism
Christopher J MorrisFrank A J L Scheer

Abstract

Shift work is a risk factor for diabetes. The separate effects of the endogenous circadian system and circadian misalignment (ie, misalignment between the central circadian pacemaker and 24-hour environmental/behavioral rhythms such as the light/dark and feeding/fasting cycles) on glucose tolerance in shift workers are unknown. The objective of the study was to test the hypothesis that the endogenous circadian system and circadian misalignment separately affect glucose tolerance in shift workers, both independently from behavioral cycle effects. A randomized, crossover study with two 3-day laboratory visits. Center for Clinical Investigation at Brigham and Women's Hospital. Healthy chronic shift workers. The intervention included simulated night work comprised of 12-hour inverted behavioral and environmental cycles (circadian misalignment) or simulated day work (circadian alignment). Postprandial glucose and insulin responses to identical meals given at 8:00 am and 8:00 pm in both protocols. Postprandial glucose was 6.5% higher at 8:00 pm than 8:00 am (circadian phase effect), independent of behavioral effects (P = .0041). Circadian misalignment increased postprandial glucose by 5.6%, independent of behavioral and circadian eff...Continue Reading

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