Effects of the isoflavone prunetin on gut health and stress response in male Drosophila melanogaster

Redox Biology
Stefanie PiegholdtAnika E Wagner

Abstract

The traditional Asian diet is rich in fruits, vegetables and soy, the latter representing a significant source of dietary isoflavones. The isoflavone prunetin was recently identified to improve intestinal epithelial barrier function in vitro and to ameliorate general survival and overall health state in vivo in male Drosophila melanogaster. However, the prunetin-mediated health benefits in the fruit fly were ascertained under standard living conditions. As the loss of intestinal integrity is closely related to a reduction in Drosophila lifespan and barrier dysfunction increases with age, effects on prunetin-modulated gut health under oxidative or pathogenic stress provocation remain to be elucidated. In this study, male adult D. melanogaster were administered either a prunetin or a control diet. Gut-derived junction protein expression and pathogen-induced antimicrobial peptide expressions as well as the stem cell proliferation in the gut were evaluated. Furthermore, survival following exposure to hydrogen peroxide was assessed. Prunetin ingestion did not attenuate bacterial infection and did not protect flies from oxidative stress. Intestinal mRNA expression levels of adherence and septate junction proteins as well as the stem ...Continue Reading

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Citations

Sep 10, 2016·The Proceedings of the Nutrition Society·Kathrin PallaufGerald Rimbach
Sep 21, 2017·Journal of Insect Science·Perumal SubramanianOnn Haji Hashim
Apr 6, 2018·Journal of Agricultural and Food Chemistry·Stefanie StaatsGerald Rimbach

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Methods Mentioned

BETA
fluorescence imaging

Software Mentioned

DLife
CellProfiler
Winchecker
SPSS
R
i386

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