Effects of the local anaesthetic ropivacaine on vascular reactivity in the mouse perfused mesenteric arteries

Basic & Clinical Pharmacology & Toxicology
Clarisse F TimponiElisardo C Vasquez

Abstract

Previous clinical and experimental studies have indicated that ropivacaine, a local anaesthetic agent, exerts vasoconstrictor effects. In this study, the contractile effects of ropivacaine were investigated in vitro on mesenteric arteriolar beds obtained from 22 adult male C57BL/6J mice. The mesenteric arteriolar bed was perfused at constant rate (2 ml/min.) with oxygenated physiological salt solution using a roller pump. First we studied the effects of ropivacaine (3.2x10(-4) to 2.2x10(-2) mol/l) on the perfusion pressure and observed a dose-dependent pressor response, reaching a maximal increase of 26.0+/-3.7 mmHg. In a second study, we observed that after the mechanical removal of the endothelium ropivacaine-induced contractile responses were significantly reduced to a maximal of 13.5+/-0.7 mmHg. In a third set of experiments, we observed that under the effect of the cyclooxygenase inhibitor indomethacin (0.01 micromol/l) the ropivacaine-induced pressor response was significantly reduced to a maximal increase of 17.5+/-0.4 mmHg. This is the first evidence that this long-acting local anesthetic causes vasoconstriction in the perfused mesenteric arteriolar bed and that, at least in part, this effect is mediated by the endothel...Continue Reading

References

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Feb 8, 2006·European Journal of Oral Sciences·Nilton E OliveiraElisardo C Vasquez

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Citations

May 4, 2010·Journal of Liposome Research·Patricia Maria Wiziack ZagoMaria Cristina Volpato
Jan 23, 2016·Anesthesia and Analgesia·José A AguirreMichael Zaugg
Dec 17, 2009·International Journal of Oral and Maxillofacial Surgery·B M B BrkovicD Stojic
Oct 20, 2007·Acta Anaesthesiologica Scandinavica·P L LinC H Huang
Mar 28, 2012·Journal of Pharmacological Sciences·Hiroki FujiwaraHiromu Kawasaki
Jul 13, 2012·Journal of Pharmacological Sciences·Hiroki FujiwaraHiromu Kawasaki
Mar 16, 2017·Clinical & Experimental Ophthalmology·Katarina CreeseSanjeewa S Wickremasinghe

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