Effects of the myocardial-selective alpha 1-adrenoceptor antagonist UK-52046 and atenolol, alone and in combination, on experimental cardiac arrhythmias in dogs

British Journal of Pharmacology
A C UprichardR G Shanks

Abstract

1. Adrenaline-induced arrhythmias in anaesthetized dogs respired with halothane were attenuated in 3 groups of 6 dogs by either UK-52046, 3.8 +/- 1.4 micrograms kg-1 (mean +/- s.e.mean), atenolol 14.6 +/- 2.1 micrograms kg-1, or a combination containing equal amounts of the two drugs of 0.36 +/- 0.1 microgram kg-1. The pressor response to adrenaline was reduced (P less than 0.01) by UK-52046 but not by atenolol or the combination of both drugs. 2. In a group of 6 dogs with multiventricular ectopic beats 24 h after coronary artery ligation (CAL), UK-52046, 32 micrograms kg-1, increased the number of sinus beats in each 5 min period from 137 +/- 47 to 662 +/- 99 (P less than 0.01); this was associated with a significant (P less than 0.01) fall in blood pressure. Atenolol in doses of up to 800 micrograms kg-1 had no effect. 3. UK-52046, 3.7 +/- 1.4 micrograms kg-1, prevented adrenaline-induced arrhythmias 3-4 days after CAL in 6/6 conscious dogs; atenolol in doses of up to 100 micrograms kg-1 produced an 84.4 +/- 7.4% reduction in the number of ventricular ectopic beats. A combination containing 3.7 +/- 1.1 micrograms kg-1 of each drug prevented the arrhythmia in 6/6 dogs. The pressor response to adrenaline was attenuated (P less ...Continue Reading

References

May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·H J SchümannG Schramm
Mar 1, 1978·Circulation·M E JosephsonJ A Kastor
Jan 1, 1985·Journal of Cardiovascular Pharmacology·D J Sheridan, W Culling
May 1, 1971·British Journal of Pharmacology·J D AllenS A Zaidi
Jun 1, 1974·British Journal of Pharmacology·J D Allen, R G Shanks
Apr 1, 1970·Cardiovascular Research·P A EbertD C Sabiston
Apr 1, 1969·Anesthesiology·L D DavisQ R Murphy
Jul 12, 1982·Life Sciences·B G Benfey
Sep 1, 1983·The Journal of Clinical Investigation·A D SharmaP B Corr
Jan 1, 1980·The Journal of Clinical Investigation·D J SheridanP B Corr
Sep 15, 1983·Toxicology and Applied Pharmacology·D J MiletichA Jozefiak
Aug 1, 1963·Circulation Research·M VASSALLEB F HOFFMAN
Aug 1, 1963·Circulation Research·J ROBERTSV J CAIROLI
Feb 1, 1965·The Journal of Pharmacology and Experimental Therapeutics·P SOMANI, B K LUM

Citations

Jun 7, 1995·Molecular and Cellular Biochemistry·M Yasutake, M Avkiran
Oct 1, 1990·British Journal of Clinical Pharmacology·J P McKaigue, D W Harron
Jan 1, 1994·Journal of Cardiovascular Electrophysiology·E VanoliP J Schwartz
Jan 1, 1991·The Journal of Pharmacy and Pharmacology·J P SpiersR Wilson
Dec 1, 1989·International Journal of Radiation Biology·A Q ZhuZ Y Luo
Mar 11, 2005·Autonomic & Autacoid Pharmacology·A T Demiryürek, S Demiryürek
Jan 1, 1994·Pharmacology & Therapeutics·R R Ruffolo, J P Hieble
Jan 1, 1990·Life Sciences·B G Benfey

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.