Effects of the Nanoparticle-Based Vaccine, SEL-068, on Nicotine Discrimination in Squirrel Monkeys

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Rajeev I Desai, Jack Bergman

Abstract

A key feature of addiction to nicotine likely resides in its ability to produce subjective effects that, in turn, may be reflected in its discriminative-stimulus properties. Vaccination against such effects of nicotine offers an intriguing therapeutic approach for smoking cessation, but a reliably effective and immunologically safe vaccine remains to be identified. Here we report on the ability of SEL-068, a nanoparticle-based vaccine that targets nicotine, to modify the discriminative-stimulus effects of nicotine in a primate species. Results indicate that squirrel monkeys vaccinated with SEL-068 failed to acquire 0.1 mg/kg nicotine discrimination but readily learned to discriminate 0.001 mg/kg of the nicotinic full agonist (+)-epibatidine ((+)-EPI). After (+)-EPI training, doses of nicotine ⩾ 0.32 mg/kg, which produced behaviorally adverse actions, still failed to substitute for the (+)-EPI training stimulus in immunized monkeys, whereas (+)-EPI and the partial agonist varenicline engendered, respectively, complete and partial substitution in all monkeys with potency comparable to their potency in non-immunized subjects. In other subjects, nicotine was trained as a discriminative-stimulus and then replaced by (+)-EPI. Subsequ...Continue Reading

References

Nov 21, 1994·Brain Research·M I DamajB R Martin
Jul 5, 2002·Respiration; International Review of Thoracic Diseases·S H L de VilliersT H Svensson
Jul 5, 2002·Respiration; International Review of Thoracic Diseases·N LindblomT H Svensson
Jan 24, 2004·Bioorganic & Medicinal Chemistry·M Rocío A CarreraKim D Janda
Feb 3, 2009·Handbook of Experimental Pharmacology·Janice W Smith, Ian P Stolerman
Feb 3, 2009·Handbook of Experimental Pharmacology·Kenneth A Perkins
Jan 25, 2011·Trends in Pharmacological Sciences·Riccardo Polosa, Neal L Benowitz
Jul 7, 2011·The Journal of Pharmacology and Experimental Therapeutics·Emily M JutkiewiczJames H Woods
Feb 24, 2012·Drugs·Tobias RaupachConstant P Onno van Schayck
Mar 23, 2012·The Journal of Pharmacology and Experimental Therapeutics·Colin S CunninghamLance R McMahon
Jan 7, 2014·The Journal of Pharmacology and Experimental Therapeutics·Rajeev I Desai, Jack Bergman
Feb 4, 2014·Advances in Pharmacology·Paul R Pentel, Mark G LeSage

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Citations

Feb 20, 2016·Psychopharmacology·Rajeev I DesaiJack Bergman
Dec 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rajeev I Desai, Jack Bergman
May 6, 2016·Annual Review of Chemical and Biomolecular Engineering·Ronnie H Fang, Liangfang Zhang
Jul 22, 2016·Human Vaccines & Immunotherapeutics·Marco Pravetoni
Jun 2, 2017·PloS One·David F ZeiglerChristopher H Clegg
Jun 3, 2017·Journal of the American Chemical Society·Paul T BremerKim D Janda
Jul 24, 2018·Nanomedicine·Huafei LiLixin Wei
Sep 19, 2017·Expert Review of Vaccines·R David HeekinThomas R Kosten
Jul 30, 2019·Advanced Materials·Peng MiKazunori Kataoka
May 23, 2018·The Journal of Pharmacology and Experimental Therapeutics·Sarah L WitheyRajeev I Desai
Jun 22, 2017·Pharmacological Reviews·Paul T Bremer, Kim D Janda
Mar 10, 2020·Annals of the New York Academy of Sciences·Ashley Xu, Thomas R Kosten
Jul 1, 2020·Immunological Reviews·Virgil SchijnsEd C Lavelle
Mar 27, 2020·Behavioural Pharmacology·Fernando B de MouraLance R McMahon
May 23, 2017·ILAR Journal·Matthew L BanksSidney S Negus
Aug 29, 2020·Cancer Research·Piotr PrzanowskiSanchita Bhatnagar

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