PMID: 16515472Mar 7, 2006Paper

Effects of the natural isoflavonoid genistein on growth, signaling pathways and gene expression of matrix macromolecules by breast cancer cells

Mini Reviews in Medicinal Chemistry
O Ch KousidouN K Karamanos

Abstract

Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17beta-estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by genistein. A critical evaluation of the effects of genistein on breast cancer growth, signaling and gene expression is presented in this review.

Citations

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