PMID: 2494282Feb 1, 1989Paper

Effects of the new prolactin-producing tumour 7315b on gonadotrophin secretion in adult male and female rats

The Journal of Endocrinology
A KooyJ T Vreeburg

Abstract

The effects of the transplantable purely prolactin-secreting tumour 7315b on serum gonadotrophins were studied in adult rats. Possible contributions of the adrenals to the tumour-induced inhibition of serum LH and FSH were evaluated. The suppressive actions of tumour 7315b on serum gonadotrophins in gonadectomized plus adrenalectomized male and female rats were compared. Within 4 weeks after inoculation of tumour 7315b in intact male rats very high levels of prolactin and decreased serum levels of gonadotrophins and testosterone were recorded. At autopsy reduced weights of testes and accessory sex organs and slightly increased adrenal weights were found. In addition, in animals treated with a small testosterone-filled capsule after castration, tumour 7315b reduced serum concentrations of LH and FSH. Adrenalectomy did not prevent this suppressive action of the tumour on the post-castration rise of serum gonadotrophins. Suppression of serum gonadotrophins during hyperprolactinaemia was greater in gonadectomized plus adrenalectomized female rats than in male rats, indicating that the degree of the tumour-induced suppression of LH and FSH after castration is determined to a large extent by the sex of the animal. The purely prolacti...Continue Reading

Citations

Feb 18, 1999·Journal of Cellular Biochemistry·M M KauP S Wang
Apr 4, 2002·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Mei-Mei KauPaulus S Wang

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