PMID: 39133Jun 1, 1979

Effects of the non-steroidal anti-inflammatory drug benoxaprofen on leucocyte migration

The Journal of Pharmacy and Pharmacology
S C Meacock, E A Kitchen


Possible modes of action of the anti-inflammatory drug, benoxaprofen, have been explored. The drug caused inhibition of leucocyte migration, principally of mononuclear cells into the pleural cavity of rats undergoing carrageenan-induced pleurisy. Evidence was obtained from in vitro leucocyte migration and chemotaxis models that the drug acted directly on the mononuclear cells rather than by inhibition of chemotactic factors.


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Related Concepts

Anti-Inflammatory Agents
Cell Motility
Chemotaxis, Leukocyte
Cavia porcellus
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