Jan 1, 1977

Effects of the number of DNP groups on dinitrophenylated human serum albumin upon the induction of immunological memory for the dinitrophenyl determinant

Archivos de investigación médica
C Larralde, D Lagunoff

Abstract

Immunological memory to the DNP determinant is shown to be a positive correlate of the primary anti-DNP response and of the extent of DNP substitution in the priming antigen. Antigen dose-response curves for immunological memory first increase with antigen dose to reach a maximum and then decrease in the high dose region. Increasing the extent of DNP substitution in the priming antigen shifts the dose-response curves to lower antigen doses and promotes the antigen's ability to induce immunological memory to a level greater than that expected by its ability to induce a primary response. The findings are interpreted in terms of postulated effects of degree of DNP substitution on the binding of antigen to cell receptors.

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Mentioned in this Paper

Nitrobenzenes
Dinitrobenzenes
Antigenic Specificity
ALB
Albumin Human, USP
Human Serum Albumin [EPC]
Dose-Response Relationship, Immunologic
Antibody Formation
Antigens
Plasma Albumin

About this Paper

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