Effects of the peripherally acting α2 -adrenoceptor antagonist MK-467 on cardiopulmonary function in sheep sedated by intramuscular administration of medetomidine and ketamine and reversed by intramuscular administration of atipamezole

American Journal of Veterinary Research
Magdy AdamO Vainio

Abstract

OBJECTIVE To evaluate effects of the peripherally acting α2-adrenoceptor antagonist MK-467 on cardiopulmonary function in sheep sedated with medetomidine and ketamine. ANIMALS 9 healthy adult female sheep. PROCEDURES Each animal received an IM injection of a combination of medetomidine (30 μg/kg) and ketamine (1 mg/kg; Med-Ket) alone and Med-Ket and 3 doses of MK-467 (150, 300, and 600 μg/kg) in a randomized blinded 4-way crossover study. Atipamezole (150 μg/kg, IM) was administered 60 minutes later to reverse sedation. Cardiopulmonary variables and sedation scores were recorded, and drug concentrations in plasma were analyzed. Data were analyzed with a repeated-measures ANCOVA and 1-way ANOVA. Reference limits for the equivalence of sedation scores were set at 0.8 and 1.25. RESULTS Heart rate, cardiac output, and Pao2 decreased and mean arterial blood pressure, central venous pressure, and systemic vascular resistance increased after Med-Ket alone. Administration of MK-467 significantly alleviated these effects, except for the decrease in cardiac output. After sedation was reversed with atipamezole, no significant differences were detected in cardiopulmonary variables among the treatments. Administration of MK-467 did not sign...Continue Reading

References

Feb 1, 1982·Anesthesiology·P F WhiteA J Trevor
May 1, 1996·Research in Veterinary Science·C E BryantJ Thompson
Feb 7, 1998·Journal of Veterinary Pharmacology and Therapeutics·C S CellyS S Young
Dec 5, 1998·Research in Veterinary Science·C E BryantK W Clarke
Dec 9, 1998·Veterinary Surgery : VS·B H Pypendop, J P Verstegen
Jan 14, 1999·Journal of Veterinary Pharmacology and Therapeutics·B RanheimN E Søli
Jan 29, 2000·Journal of Veterinary Pharmacology and Therapeutics·B RanheimT E Horsberg
May 29, 2000·Journal of the American Veterinary Medical Association·J C KoR E Mandsager
Feb 13, 2001·Journal of Veterinary Pharmacology and Therapeutics·B RanheimJ M Arnemo
Feb 13, 2001·Journal of Veterinary Pharmacology and Therapeutics·B RanheimT E Horsberg
Aug 11, 2001·American Journal of Veterinary Research·D J MasonW McDonell
Jan 14, 2003·Journal of the American Veterinary Medical Association·André L SelmiGlenda R Barbudo-Selmi
Jul 31, 2003·Journal of Veterinary Pharmacology and Therapeutics·S B R KästnerM Huhtinen
Nov 24, 2004·European Journal of Pharmacology·Veronica FagerholmMerja Haaparanta
Jan 17, 2007·Research in Veterinary Science·S B R KästnerM K Huhtinen
Jul 1, 2008·Pharmacology, Biochemistry, and Behavior·Joseph R HoltmanElzbieta P Wala
Aug 13, 2011·Veterinary Anaesthesia and Analgesia·Flavia RestituttiOuti M Vainio
Nov 25, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Juhana HonkavaaraMika Scheinin
Nov 21, 2012·British Journal of Anaesthesia·T D AmbriskoY Moens
Feb 21, 2016·Journal of Veterinary Pharmacology and Therapeutics·B H PypendopJ E Ilkiw
Nov 29, 2016·Veterinary Surgery : VS·Heidi TapioMarja Raekallio

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Citations

Apr 7, 2021·Veterinary Anaesthesia and Analgesia·Eva M GreunzMads F Bertelsen
Sep 4, 2021·Journal of Veterinary Pharmacology and Therapeutics·Magdy AdamKati Salla

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