Effects of the phosphodiesterase IV inhibitor rolipram on Th1 and Th2 immune responses in mice

The Journal of Pharmacy and Pharmacology
Kouya YamakiShin Yoshino

Abstract

The present study was designed to investigate the effect of the phosphodiesterase IV inhibitor rolipram on Th1 and Th2 immune responses in mice. Mice were immunized subcutaneously at the base of the tail with ovalbumin (OVA) emulsified with complete Freund's adjuvant (day 0) and were treated daily with oral administration of various doses of rolipram from days 0 to 20. On day 21, production of anti-OVA IgG and proliferative responses to the antigen were determined. Anti-OVA IgG2a and interferon-gamma (IFN-gamma), as indicators of Th1 responses, and anti-OVA IgG1 and interleukin-10 (IL-10), as indicators of Th2 responses, were also measured. The results showed that treatment with rolipram failed to affect the production of OVA-specific IgG but decreased the proliferation of spleen cells to the antigen. Its inhibitory effect on these immune responses was correlated with a marked decrease in IFN-gamma but not IL-10 production, although neither anti-OVA IgG2a nor IgG1 production was affected by rolipram. These results suggest that rolipram may preferentially inhibit Th1 responses more effectively than Th2 responses. Administration of rolipram resulted in suppression of antigen (OVA)-induced arthritis in mice. The suppression of joi...Continue Reading

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Citations

Feb 13, 2010·Autoimmunity Reviews·Padmanabha Shenoy, Vikas Agarwal
Dec 18, 2013·International Immunopharmacology·Kouya Yamaki, Shin Yoshino
Dec 23, 2008·Toxicology Letters·Kiyoshi KushimaMichio Fujiwara
Aug 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kevin KellyRicardo C T Aguiar

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