PMID: 3755490Jul 21, 1986Paper

Effects of the platelet-activating factor antagonist BN 52021 on the hemodynamics of rats with experimental cirrhosis of the liver

Life Sciences
L M VillamedianaJ M López-Novoa

Abstract

Previous studies from this laboratory have shown that rats with experimental cirrhosis of the liver induced by the combined administration of oral phenobarbital and inhaled carbon tetrachloride show an hyperdynamic status with enhanced cardiac output (CO), and decreased mean arterial pressure (MAP) and peripheral vascular resistance (PVR). Cirrhotic rats also showed an increased vascular permeability. All these phenomena are similar to some of the known effects of the systemic infusion of low doses of synthetic platelet-activating factor into the systemic circulation of normal rats. The measurement of the levels of platelet-activating factor in samples of blood demonstrated significantly higher levels in cirrhotic (2.65 +/- 0.39; n = 10) than in control rats (1.50 +/- 0.57 ng/ml; n = 10; p less than 0.05). The hemodynamic changes induced by the intravenous injection of the platelet-activating factor receptor antagonist BN 52021 (5 mg/kg body weight) have been measured in 10 control and 10 cirrhotic male Wistar rats, using a radioactive microsphere technique. BN 52021 induced no significant hemodynamic changes in control animals. However, in cirrhotic animals it induced a significant decrease in CO with increase in PVR. MAP incr...Continue Reading

References

Oct 29, 1979·Biochemical and Biophysical Research Communications·M L BlankE E Muirhead
Jul 16, 1986·Biochemical and Biophysical Research Communications·D Rodríguez-PuyolJ M López-Novoa
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C CarameloL Hernando
Feb 26, 1985·European Journal of Pharmacology·Z TerashitaS Sumida
Jan 21, 1983·European Journal of Pharmacology·P BessinJ Benveniste
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M López-NovoaL Hernando
May 16, 1984·Biochemical and Biophysical Research Communications·C CarameloM Sanchez Crespo

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Citations

Sep 1, 1991·Digestive Diseases and Sciences·S H ThomasJ N Benoit
Jan 1, 1993·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·H P Li, R X Zhang
May 1, 1989·The Journal of Clinical Investigation·F Lopez DiezM Sanchez Crespo
Feb 27, 2009·Digestive Diseases and Sciences·Haralabos C KarantonisStamatios E Theocharis
Feb 1, 1987·European Journal of Clinical Investigation·C CarameloL Hernando
Jul 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A M AghaM T Khayyal
Jun 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Reichen
Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S S LeeJ M Pak
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F GuarnerJ Rodés
Oct 1, 1992·Alimentary Pharmacology & Therapeutics·R D Grose, P C Hayes
Jun 15, 2006·World Journal of Gastroenterology : WJG·Nikolaos-P KaridisStamatios-E Theocharis

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