Effects of the polyphenol resveratrol on contractility of human term pregnant myometrium

Molecular Human Reproduction
Radmila NovakovicLjiljana Gojkovic-Bukarica

Abstract

The ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study evaluated the effect of resveratrol on the oxytocin-induced contractions of human term pregnant myometrium in vitro and the contribution of different K(+) channels to resveratrol action. Resveratrol induced a concentration-dependent relaxation of myometrium contractions (pD2 value and maximal responses were 4.52 and 82.25%, respectively). Glibenclamide, a selective blocker of ATP-sensitive (KATP), iberiotoxin, a selective blockers of big-calcium sensitive (BK(Ca)) and 4-aminopiridine, a non-selective blocker of voltage-sensitive (Kv) channels induced a significant shift to the right of the concentration-response curves of resveratrol. Inhibition achieved by 0.1 mM resveratrol was insensitive to all K(+) channel blockers. A K(+) channel opener, pinacidil, inhibited oxytocin-induced contractions of pregnant myometrium with comparable potency and efficacy to resveratrol (pD2 values and maximal relaxation were 4.52 and 83.67%, respectively). Based on K(+) channel...Continue Reading

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Citations

Dec 3, 2015·Reproductive Sciences·Ayumi TaguchiTomoyuki Fujii
Aug 16, 2017·Molecular Human Reproduction·María Victoria BarianiAna María Franchi
Jun 21, 2020·European Journal of Pharmacology·Vladimir DjokicLjiljana Gojkovic-Bukarica
Apr 16, 2020·Expert Opinion on Investigational Drugs·Tegan TriggsMurray Mitchell
Nov 2, 2019·Experimental and Molecular Pathology·Vladimir DjokicLjiljana Gojkovic-Bukarica

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