Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson's disease models.

Aging
Vanessa CastelliAnnamaria Cimini

Abstract

Parkinson is a common neurodegenerative disorder, characterized by motor and non-motor symptoms, including abnormalities in the gut function, which may appear before the motor sign. To date, there are treatments that can help relieve Parkinson' disease (PD)-associated symptoms, but there is no cure to control the onset and progression of this disorder. Altered components of the gut could represent a key role in gut-brain axis, which is a bidirectional system between the central nervous system and the enteric nervous system. Diet can alter the microbiota composition, affecting gut-brain axis function. Gut microbiome restoration through selected probiotics' administration has been reported. In this study, we investigated the effects of the novel formulation SLAB51 in PD. Our findings indicate that this probiotic formulation can counteract the detrimental effect of 6-OHDA in vitro and in vivo models of PD. The results suggest that SLAB51 can be a promising candidate for the prevention or as coadjuvant treatment of PD.

References

Mar 26, 2008·Neurochemical Research·Rebecca L MillerAlbert Y Sun
Feb 24, 2012·Gut Microbes·Hsin-Jung Wu, Eric Wu
Jun 8, 2012·Cold Spring Harbor Perspectives in Medicine·João Massano, Kailash P Bhatia
Dec 25, 2012·Journal of Neurology·Maria G CersosimoEduardo E Benarroch
Nov 21, 2013·Journal of Parkinson's Disease·Vera DiasM Maral Mouradian
Apr 24, 2015·Lancet·Lorraine V Kalia, Anthony E Lang
Jun 20, 2015·Journal of Movement Disorders·Hye Mi Lee, Seong-Beom Koh
Oct 28, 2015·Nature Reviews. Neurology·Lisa Klingelhoefer, Heinz Reichmann
Jun 25, 2016·International Journal of Molecular Sciences·Sumit SarkarSyed Imam
Jun 27, 2017·NPJ Parkinson's Disease·Madelyn C Houser, Malú G Tansey
Oct 19, 2017·Acta Neuropathologica·Arthur LionnetThomas G Beach
Dec 5, 2017·Current Behavioral Neuroscience Reports·Paula Perez-PardoAletta D Kraneveld
Jan 15, 2018·Neurobiology of Aging·Manuela BombaStefano L Sensi
Feb 22, 2018·Neural Plasticity·Enrico SangiovanniFrancesca Calabrese
Mar 2, 2018·The Journal of Microbiology·Namhee KimHak-Jong Choi
May 3, 2018·Frontiers in Aging Neuroscience·Xian-Si ZengPeng-Peng Zhang
Jul 3, 2018·Oncotarget·Vanessa CastelliAnnamaria Cimini
Jul 20, 2018·Cellular and Molecular Gastroenterology and Hepatology·Clair R MartinEmeran A Mayer
Dec 14, 2018·Frontiers in Aging Neuroscience·Guoxin ZhangTao Wang
May 28, 2019·Frontiers in Immunology·Luca MagistrelliCristoforo Comi
Jun 9, 2019·Parkinsonism & Related Disorders·Daniele PietrucciAlessandro Desideri
Jun 14, 2019·Frontiers in Molecular Neuroscience·Vanessa CastelliMichele d'Angelo
Aug 28, 2019·International Journal of Molecular Sciences·Parisa Gazerani
Oct 17, 2019·International Journal of Molecular Sciences·Michele d'AngeloAnnamaria Cimini

❮ Previous
Next ❯

Citations

Oct 8, 2020·Stem Cells Translational Medicine·Vanessa CastelliAnnamaria Cimini
Jul 29, 2020·International Journal of Molecular Sciences·Michele d'AngeloVanessa Castelli
Oct 10, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ethan G Brown, Samuel M Goldman
Oct 13, 2020·Frontiers in Microbiology·Maria AponteMahtab Shoukat
Feb 16, 2021·Research in Veterinary Science·Giacomo RossiSara Mangiaterra
Oct 24, 2020·Nature Reviews. Microbiology·Livia H MoraisSarkis K Mazmanian
Jan 29, 2021·Frontiers in Nutrition·Giancarlo CeccarelliGabriella d'Ettorre
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elena Barengolts, Emily Daviau Smith
Jan 13, 2021·Marine Drugs·Mariano CatanesiAnnamaria Cimini
Apr 4, 2021·Biomedicines·Mariarosaria CuozzoRoberto Russo
Apr 17, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Ai Huey TanShen-Yang Lim
Oct 17, 2020·Neural Regeneration Research·Vanessa CastelliAnnamaria Cimini
Jun 26, 2021·Neuroscience and Biobehavioral Reviews·Jessica EastwoodDaniel Lamport
Jul 21, 2021·Cellular and Molecular Neurobiology·Hamed MirzaeiOmid Reza Tamtaji
Jul 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Geir BjørklundMichael Maes
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Katarzyna SocałaPiotr Wlaź

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy
amplification sequencing
ELISA

Software Mentioned

PRISM
ImageJ

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.