Effects of the rotavirus vaccine program across age groups in the United States: analysis of national claims data, 2001-2016

BMC Infectious Diseases
Julia M BakerBenjamin A Lopman

Abstract

The direct effectiveness of infant rotavirus vaccination implemented in 2006 in the United States has been evaluated extensively, however, understanding of population-level vaccine effectiveness (VE) is still incomplete. We analyzed time series data on rotavirus gastroenteritis (RVGE) and all-cause acute gastroenteritis (AGE) hospitalization rates in the United States from the MarketScan® Research Databases for July 2001-June 2016. Individuals were grouped into ages 0-4, 5-9, 10-14, 15-24, 25-44, and 45-64 years. Negative binomial regression models were fitted to monthly RVGE and AGE data to estimate the direct, indirect, overall, and total VE. A total of 9211 RVGE and 726,528 AGE hospitalizations were analyzed. Children 0-4 years of age had the largest declines in RVGE hospitalizations with direct VE of 87% (95% CI: 83, 90%). Substantial indirect effects were observed across age groups and generally declined in each older group. Overall VE against RVGE hospitalizations for all ages combined was 69% (95% CI: 62, 76%). Total VE was highest among young children; a vaccinated child in the post-vaccine era has a 95% reduced risk of RVGE hospitalization compared to a child in the pre-vaccine era. We observed higher direct VE in odd ...Continue Reading

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Citations

Dec 19, 2019·Current Opinion in Pediatrics·Mélanie SicardCaroline Quach
Aug 22, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Sylvie EscolanoPascale Tubert-Bitter
Nov 20, 2020·The Journal of Infectious Diseases·Daniel C PayneArdythe L Morrow
Nov 23, 2020·Vaccine·Karene Hoi Ting YeungE Anthony S Nelson
May 27, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anthony T NewallUmesh Parashar
Sep 7, 2021·Expert Opinion on Biological Therapy·Jordan E CatesUmesh Parashar

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