PMID: 7520510May 1, 1994Paper

Effects of the short-chain triglyceride triacetin on intestinal mucosa and metabolic substrates in rats

JPEN. Journal of Parenteral and Enteral Nutrition
J W LynchJ W Bailey

Abstract

Diets containing either triacetin (the water-soluble triglyceride of acetate) or long-chain triglycerides (LCTs) were fed to rats to determine the effects on intestinal mucosa cells and plasma substrates. Male Sprague-Dawley rats were fed one of three diets, a control diet containing 5% of energy as LCTs or one of two experimental diets that contained 30% of energy as lipid. The lipid component of the two experimental diets was either 100% LCTs or 95% triacetin/5% LCTs. Plasma lactate, glucose, and total ketone body concentrations were not significantly different among dietary treatment groups. Compared with animals fed LCTs and control diet, plasma pyruvate and free fatty acid concentrations were decreased in animals fed triacetin. In contrast, plasma triglyceride concentrations were elevated in animals fed triacetin compared with other groups. Intestinal biochemical measures included total DNA, RNA, protein, and the protein:DNA ratio. Histologic indices measured were villus height in the jejunum and crypt depth in the colon. No significant difference in mucosal protein concentration was observed in the jejunum and colon. Jejunal RNA was significantly decreased in animals fed triacetin compared with other diets. Triacetin feed...Continue Reading

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Citations

Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·D Boggio BertinetF Balzola
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Claude C RoyEmile Levy
Oct 27, 2018·International Journal of Molecular Sciences·Tao WuGuoyao Wu

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