Effects of the source gap on transmission efficiency of a quadrupole mass spectrometer

Rapid Communications in Mass Spectrometry : RCM
Mariya J Antony JosephStephen Taylor

Abstract

Recent trends towards miniature and portable quadrupole mass spectrometry (QMS) entail challenges in instrumental sensitivity, which is influenced by 3D fringe field effects on ion transmission in the Quadrupole Mass Filter (QMF). The relationship of these effects with the gap from the ion source to the QMF entrance (source gap) is significant and little explored. We examine transmission characteristics experimentally and use the results to test the predictive accuracy of a recently developed 3D QMF simulation model. The model is then applied to directly investigate optimal transmission m/z ranges across multiple source gaps. A portable single filter quadrupole mass spectrometer is used to analyse transmission characteristics across a range of common gases. We use an experimental approach originally proposed by Ehlert, enhanced with a novel method for absolute calibration of the transmission curve. Custom QMF simulation software employs the boundary element method (BEM) to compute accurate 3D electric fields. This is used to study the effects of the source gap on transmission efficiency. Experimental findings confirm a centrally peaked transmission curve; simulations correctly predict the optimal transmission location (in m/z) ...Continue Reading

References

Aug 30, 2000·Rapid Communications in Mass Spectrometry : RCM·J R Gibson, S Taylor
Jun 13, 2001·Journal of the American Society for Mass Spectrometry·S Boumsellek, R J Ferran
Dec 14, 2007·Journal of Mass Spectrometry : JMS·Stephen Taylor, John R Gibson
Jun 6, 2009·Mass Spectrometry Reviews·D J Douglas
Jan 30, 2010·Analytical Chemistry·Andrew MalcolmAlan Finlay
Mar 4, 2010·Journal of Mass Spectrometry : JMS·J Raymond GibsonStephen Taylor
Jul 11, 2012·Journal of the American Society for Mass Spectrometry·John R GibsonStephen Taylor
Nov 19, 2014·Journal of the American Society for Mass Spectrometry·Chien-Hsun ChenZheng Ouyang
Feb 25, 2015·Analytical Chemistry·Steven WrightRichard R A Syms

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society for Mass Spectrometry
Sarfaraz U A H SyedStephen Taylor
Journal of the American Society for Mass Spectrometry
Boris BrkićStephen Taylor
© 2022 Meta ULC. All rights reserved