Effects of the statin antihyperlipidemic agent simvastatin on grass shrimp, Palaemonetes pugio

Environmental Toxicology
Peter B KeyMichael H Fulton

Abstract

This study investigated lethal effects (i.e., survival) and sublethal effects (glutathione, GSH; lipid peroxidation, LPx; cholesterol, CHL; and acetylcholinesterase, AChE) of the antihyperlipidemic drug simvastatin on larval and adult grass shrimp (Palaemonetes pugio). The 96-h LC50 test for larvae resulted in an estimated LC50 of 1.18 mg/L (95% confidence interval 0.98-1.42 mg/L). The adult 96-h LC50 was >10.0 mg/L. GSH and AChE levels for both the larvae and the adults were not significantly affected by simvastatin exposure. LPx levels in the larvae were significantly higher than controls in the lowest and the highest simvastatin exposures. In adult grass shrimp, LPx levels were highest in the three lowest simvastatin exposures. CHL levels were significantly reduced in larvae at the highest simvastatin exposure level of 1 mg/L while adult CHL was not affected. Both lethal and sublethal effects associated with simvastatin exposure were only observed at concentrations well above those reported in the environment.

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Citations

Sep 12, 2007·Archives of Environmental Contamination and Toxicology·Marie E DeLorenzo, Jessica Fleming
Dec 4, 2009·Journal of Hazardous Materials·Lúcia H M L M SantosM C B S M Montenegro
Apr 5, 2016·Environmental Science and Pollution Research International·V CunhaM Ferreira
Jul 7, 2017·Journal of Toxicology and Environmental Health. Part a·V CunhaM Ferreira
Apr 15, 2009·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Peter B KeyMichael H Fulton
Apr 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·André PereiraAngelina Pena

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