Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract.

Biochimica Et Biophysica Acta
E M van LieshoutW H Peters

Abstract

Several dietary compounds have been demonstrated to reduce gastrointestinal cancer rates in both humans and animals. We showed that high human gastrointestinal tissue levels of glutathione S-transferase (GST), a family of detoxification enzymes consisting of class Alpha, Mu, Pi and Theta isoforms, were inversely correlated with cancer risk. We now investigated whether the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen, supplemented in the diet for two weeks at 1450, 250, 10,000, and 200 ppm, respectively, influenced (i) GST activity, (ii) GST isoenzyme levels, (iii) GSH levels, or (iv) glutathione peroxidase (GPx) activity in the gastrointestinal tract of male Wistar rats. Sulforaphane analog compound 30 enhanced GST activity in all organs studied (1.2-2.4 x). It induced GST Alpha levels in small intestine and liver, GST Mu levels in stomach and small intestine, GST Pi levels in stomach and small and large intestine, and GSH levels in stomach and proximal and middle small intestine. Indole-3-carbinol induced gastric GST Mu and hepatic GST Alpha levels. D-limonene induced hepatic GST Alpha, colonic GST Pi levels and proximal small intestinal GST enzyme activity and GST Pi levels. Relafen induced hepati...Continue Reading

References

Jul 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H M WortelboerH E Falke
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangG H Posner
Jun 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H G Shertzer, M Sainsbury
Apr 24, 1991·Biochimica Et Biophysica Acta·W L Smith, L J Marnett
Apr 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H G Shertzer, M Sainsbury
Nov 1, 1989·Carcinogenesis·W A RussinM N Gould
Dec 1, 1989·Carcinogenesis·W H PetersT Wobbes
Dec 1, 1988·Mutation Research·H HayatsuT Negishi
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B MannervikH Jörnvall
Jan 1, 1985·Methods in Enzymology·B Mannervik
Feb 9, 1973·Science·J T RotruckW G Hoekstra
May 15, 1973·FEBS Letters·L FloheH H Schock
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C A Bradfield, L F Bjeldanes
Dec 1, 1994·Cancer Metastasis Reviews·M J Thun
Apr 1, 1995·Carcinogenesis·H VerhagenP J van Bladeren
May 1, 1994·Digestive Diseases·T Lancaster, C Silagy
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangP Talalay
Jul 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M M Reicks, D Crankshaw
Jan 1, 1993·Advances in Enzyme Regulation·T PresteraP Talalay
Aug 9, 1993·The American Journal of Medicine·D E HillemanB D Lucas
Jun 1, 1993·British Journal of Cancer·W H PetersJ B Jansen

❮ Previous
Next ❯

Citations

Jul 13, 2000·European Journal of Drug Metabolism and Pharmacokinetics·O VangO Andersen
Mar 30, 2011·European Journal of Nutrition·Jesudoss Victor Antony SantiagoNamasivayam Nalini
Jun 25, 2002·Molecular Aspects of Medicine·David G Lindsay, Siân B Astley
Jul 23, 1999·Mutation Research·M L van IerselP J van Bladeren
Oct 18, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C LoguercioC Del Vecchio Blanco
Jul 16, 2004·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Kasi Pandima DeviWilliam Selvamurthy
Mar 10, 2001·Free Radical Research·B HalliwellM Whiteman
Jul 19, 2006·Current Medical Research and Opinion·H HoenschW Kirch
May 17, 2014·Phytotherapy Research : PTR·Jean-François LesgardsSylvia Pietri
Apr 17, 2013·Toxicology and Industrial Health·D Senthil KumarN Anitha
Sep 25, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tamara Raphael KnightCurtis D Klaassen
Apr 13, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S GedikE Altinoz
Apr 27, 2018·Journal of Biomolecular Structure & Dynamics·Gholamhossein Sodeifian, Fariba Razmimanesh
Oct 3, 2009·Basic & Clinical Pharmacology & Toxicology·Davicino RobertoClaudia Anesini
Apr 25, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joana SantiagoMargarida Fardilha
Feb 24, 2001·Drug Metabolism and Drug Interactions·H G Shertzer, A P Senft
May 25, 2012·Proteomics·Nisha VermaSimone Schmitz-Spanke
Jun 18, 2005·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Ritu AnejaRamesh Chandra
Jan 11, 2005·The American Journal of Clinical Nutrition·Barry HalliwellAndrew Jenner
Nov 20, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Laurence S Kaminsky, Qing-Yu Zhang
Feb 10, 2012·Human & Experimental Toxicology·S C ChaudharyM Sarwar Alam
Jan 8, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Heather JefferiesRosalie D McCauley
Sep 12, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sema GedikEyup Altinoz

❮ Previous
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