Effects of the taurine transport antagonist, guanidinoethane sulfonate, and beta-alanine on the morphology of rat retina

Journal of Neuroscience Research
H Pasantes-MoralesR J Huxtable

Abstract

Newborn rats treated for the first weeks of life with guanidinoethane sulfonate (GES), a blocker of taurine transport producing taurine depletion, showed a severe disruption of photoreceptor structure. Photoreceptor damage consisted of a marked reduction of the size of the photoreceptor layer, deformation of the outer segments, and a profound disorganization of the disc membranes. The GES-induced degeneration pattern was very similar to that observed in cats fed a taurine-deficient diet. Injection of beta-alanine, another antagonist of taurine transport, also produced a disruption of photoreceptor structure. These results confirm the requirement of taurine for maintaining photoreceptor structure in different species.

References

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Citations

Apr 1, 1990·Documenta Ophthalmologica. Advances in Ophthalmology·B RicciN Maggiano
Apr 1, 1994·Neurochemical Research·J MoránH Pasantes-Morales
Jan 14, 1986·European Journal of Pharmacology·S M LiebowitzC I Allen
May 1, 1991·Brain Research. Brain Research Reviews·J B Lombardini
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L LimaB Drujan
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L LimaB Drujan
Jan 1, 1986·Journal of Neuroscience Research·P SalazarH Pasantes-Morales
Jun 6, 2003·Clinical & Experimental Ophthalmology·Michelle LoeligerSandra M Rees
Jan 1, 1988·Experimental Eye Research·O QuesadaH Pasantes-Morales
Jan 1, 1984·Journal of Neuroscience Research·O QuesadaH Pasantes-Morales
Jan 1, 1984·Journal of Neuroscience Research·H Pasantes-Morales, C Cruz
Jan 1, 1987·Journal of Neuroscience Research·M Neuringer, J Sturman
Jul 1, 1986·Experimental Eye Research·H Pasantes-MoralesP Pacheco
Jun 15, 1985·Biochemical Pharmacology·H Pasantes-MoralesG E Gaull
Apr 20, 2016·European Journal of Pharmacology·Dario RuscianoSalvatore Pezzino
Apr 12, 2014·Progress in Retinal and Eye Research·Nicolas FrogerSerge Picaud
Oct 31, 2002·The European Journal of Neuroscience·A N ChepkovaO A Sergeeva
Jul 1, 1987·Biochemical Pharmacology·S M LiebowitzP S Salva
May 10, 2002·Nutritional Neuroscience·Julius D Militante, John B Lombardini
Apr 1, 1988·Journal of Neuroscience Research·R López-EscaleraH Pasantes-Morales
Jan 1, 1989·Progress in Neurobiology·R J Huxtable
Dec 1, 1987·Experimental Eye Research·J MoranH Pasantes-Morales
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chian Ju JongStephen W Schaffer

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