PMID: 6166818Mar 1, 1981Paper

Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. III. Biochemical and morphometric parameters of the liver

Mechanisms of Ageing and Development
Eduardo A PortaR T Nitta

Abstract

The purpose of this study was to explore in rats the possible influence of the type of dietary fat at two extreme levels of vitamin E on several biochemically determined hepatic changes and on a number of quantitatively analyzed structural and ultrastructural variations with age in hepatic cells. Six groups of weanling Wistar male rats were fed ad libitum isoenergetic diets containing similar amounts (15 g per 100 g diet) of saturated fat (coconut oil), unsaturated fat (safflower oil) or a combination of both at two levels of dl-alpha-tocopherol (2 or 200 mg per 100 g of diet). Determinations were performed in rats killed at 3, 6, 12, 18 and 24 months. Although in relation to age and irrespective of the type of diet, several of the biochemical parameters fluctuated with time, comparisons of the results between the youngest and oldest rats showed no changes in the levels of hepatic RNA, phospholipids, cholesterol, total tocopherols and total collagens, significant increases in DNA and triglycerides and a significant decrease in total protein. While the type of diet did not have in general significant influences on the levels of DNA, RNA, total protein and collagens, either the type of dietary fat and/or the levels of vitamin E h...Continue Reading

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Citations

Oct 1, 1988·Mechanisms of Ageing and Development·L PénzesO Regius
Oct 1, 1989·Mechanisms of Ageing and Development·L Dini, L Conti Devirgiliis
Mar 1, 1991·Archives of Gerontology and Geriatrics·E A Porta
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Feb 7, 2004·Archives of Gerontology and Geriatrics·Eduardo A Porta
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Jun 3, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ricardo MarcosAna Patrícia Fontes-Sousa
Apr 27, 2002·Annals of the New York Academy of Sciences·Eduardo A Porta
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