PMID: 7035921Oct 1, 1981Paper

Effects of the umuC36 mutation on ultraviolet-radiation-induced base-change and frameshift mutations in Escherichia coli

Mutation Research
T Kato, E Nakano

Abstract

The effects of the umuC36 mutation on the induction of base-change and frameshift mutations were studied. An active umuC gene was necessary in either the uvr+ strains of Escherichia coli K12 for UV- and X-ray-induced mutations to His+, ColER and SpcR, which are presumably base-change mutations, but it was not essential for ethyl methanesulphonate or N-methyl-N'-nitro-N-nitrosoguanidine-induced His+ mutations. In contrast, only 1 out of 13 trp- frameshift mutations examined was UV reversible, and the process of mutagenesis was umuC+-dependent, whereas a potent frameshift mutagen, ICR191, effectively induced Trp+ mutations in most of the strains regardless of the umu+ or umuC genetic background. These results suggest that base substitutions are a major mutational type derived from the umuC+-dependent pathway of error-prone repair.

References

Jun 25, 1979·Journal of Molecular Biology·J H Miller, U Schmeissner
Jun 15, 1978·Journal of Molecular Biology·C W Lawrence, R B Christensen
Nov 1, 1978·Mutation Research·B A Bridges, R P Mottershead
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·E M Witkin, I E Wermundsen
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·M RadmanS Spadari
Dec 15, 1977·Journal of Molecular Biology·C Coulondre, J H Miller
Jan 1, 1976·Annual Review of Biochemistry·J W Drake, R H Baltz
Oct 18, 1976·Molecular & General Genetics : MGG·M DefaisM Radman
Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S G Sedgwick
Apr 28, 1972·Journal of Molecular Biology·M L Meistrich, J W Drake
Oct 15, 1974·Journal of Molecular Biology·T Kohno, J R Roth
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S C WestP Howard-Flanders
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C J Kenyon, G C Walker
Jan 1, 1980·Molecular & General Genetics : MGG·P F Schendel, M Defais

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Citations

Aug 1, 1989·Molecular & General Genetics : MGG·S G SedgwickP Strike
Jan 1, 1984·Molecular & General Genetics : MGG·C W LawrenceJ Bond
Jan 1, 1983·Molecular & General Genetics : MGG·M Defais
Jan 1, 1992·Radiation and Environmental Biophysics·K KoudelaJ Slotova
Feb 20, 1987·Journal of Molecular Biology·N Koffel-SchwartzR P Fuchs
Jul 1, 1985·Mutation Research·N J Sargentini, K C Smith
Dec 1, 1989·Mutation Research·B TokarovaE A Krasavin
Sep 1, 1989·Mutation Research·K WatanabeY Shirasu
Jan 22, 2002·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A TakahashiT Ohnishi
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S G Sedgwick, P A Goodwin
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y KitagawaT Kato
Jul 27, 2002·Journal of Bacteriology·Damian GawelIwona J Fijalkowska
May 25, 2006·Annual Review of Microbiology·Takehiko Nohmi
Jun 1, 1992·International Journal of Radiation Biology·S KozubekG Horneck
Jan 1, 1993·Critical Reviews in Biochemistry and Molecular Biology·Z LivnehT Elizur
Jul 25, 1984·Journal of Molecular Biology·G Maenhaut-Michel, P Caillet-Fauquet
Dec 5, 1984·Journal of Molecular Biology·J E LeClercR Allen

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