Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, short-term exploratory modulation and spatial memory in awake, freely moving rats

The European Journal of Neuroscience
C A BarnesC G Parsons

Abstract

Chronic treatment of adult male F-344 rats (9-12 months old) with therapeutically relevant doses of memantine (30 mg/kg/day in chow for > 8 weeks) increased the maintenance of long-term potentiation of field excitatory postsynaptic potentials from perforant path-granule cell hippocampal synapses recorded in the fascia dentata in vivo. In contrast, there was no effect of memantine on baseline synaptic responses or population spikes. Likewise, short-term exploratory modulation of these hippocampal evoked responses was not different between memantine-treated and control rats. Both groups of rats were able to learn the spatial version of the Morris water task equally well, but the memantine-treated group showed a strong tendency to show more selective spatial search patterns in the training quadrant of the water pool during a final probe trial. As such, these studies provide the first electrophysiological evidence that memantine can increase the durability of synaptic plasticity and provide preclinical confirmation of the cognitive improvement seen with memantine in the treatment of demented patients.

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Nov 27, 1992·Science·J D ClementsG L Westbrook
Jul 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M Palmer, S Gershon
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·L WardW C Abraham
Jan 1, 1989·Experimental Brain Research·C MondadoriG E Fagg
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·J T GreenamyreA B Young
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1985·Annals of the New York Academy of Sciences·L de Toledo-Morrell, F Morrell
Apr 1, 1984·Canadian Journal of Physiology and Pharmacology·G L CollingridgeH McLennan
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Jan 1, 1995·Journal of Physiology, Paris·H J Kang, E M Schuman
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·W DanyszG Quack
Nov 1, 1993·Behavioral and Neural Biology·R LedererC Mondadori
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Aug 1, 1995·Behavioural Pharmacology·W. DanyszC.G. Parsons
Jun 1, 1994·Amino Acids·W Danysz, T Archer

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Citations

Nov 24, 2007·Psychopharmacology·Daniel BeracocheaPhilippe Morain
Jan 29, 2011·Psychopharmacology·Matthias VandesquilleDaniel Béracochéa
Nov 8, 2001·European Journal of Pharmacology·C G Parsons
Aug 23, 2001·Brain Research. Brain Research Reviews·R D'Hooge, P P De Deyn
Nov 24, 1999·Brain Research. Brain Research Reviews·T C Foster
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Apr 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hongxin DongJohn G Csernansky
May 11, 2011·Journal of Medicinal Food·Vijayasree V GiridharanTetsuya Konishi
Nov 1, 2002·International Clinical Psychopharmacology·G WilcockUNKNOWN MMM 500 group
Sep 1, 2007·Behavioural Pharmacology·Carla M YuedeJohn G Csernansky
Jun 4, 2010·Behavioural Pharmacology·Ana Cristina G SouzaCristina Wayne Nogueira
Aug 30, 2012·The American Journal of Chinese Medicine·Xiaotong LiuJong Hoon Ryu
Jan 8, 2008·Biological & Pharmaceutical Bulletin·Tran Manh HungKihwan Bae
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lesley A SchimanskiCarol A Barnes
Jun 28, 2003·CNS Drugs·D Allan Butterfield, Chava B Pocernich
Sep 1, 2008·Expert Opinion on Drug Discovery·Arjan Blokland, Frank Boess
Nov 4, 2000·Expert Opinion on Investigational Drugs·K K Jain
Sep 15, 2010·Life Sciences·Sunita SharmaHolly Brown-Borg
Apr 7, 2010·Behavioural Brain Research·Jason LockrowAnn-Charlotte Granholm
Jun 28, 2008·European Journal of Pharmacology·Jorge CamarasaDavid Pubill
Feb 5, 2008·Behavioural Brain Research·Amber M Muehlmann, Darragh P Devine
Jul 14, 2007·European Journal of Pharmacology·Nikolaos Pitsikas, Nikolaos Sakellaridis
Jan 2, 2007·Neurobiology of Learning and Memory·Dong Hyun KimJong Hoon Ryu
Jun 28, 2011·Basic & Clinical Pharmacology & Toxicology·Édina Madeira FloresJaqueline Nascimento Picada
Oct 6, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Xu JieLi Yan
Nov 3, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S K SonkusareP Ramarao
Jul 11, 2006·European Journal of Pharmacology·Dong Hyun KimJong Hoon Ryu

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