PMID: 9447857Feb 3, 1998Paper

Effects of the water content of soda lime on compound A concentration in the anesthesia circuit in sevoflurane anesthesia

Anesthesiology
H BitoK Ikeda

Abstract

Sevoflurane anesthesia is usually performed with fresh gas flow rates greater than 2 l/min due to the toxicity of compound A in rats and limited clinical experience with sevoflurane in low-flow systems. However, to reduce costs, it would be useful to identify ways to reduce compound A concentrations in low-flow sevoflurane anesthesia. This goal of this study was to determine if compound A concentrations can be reduced by using soda lime with water added. Low-flow sevoflurane anesthesia (fresh gas flow of 1 l/min) was performed in 37 patients using soda lime with water added (perhydrated soda lime) or standard soda lime as the carbon dioxide (CO2) absorbent. The soda lime was not changed between patients, but rather was used until CO2 rebreathing occurred. The perhydrated soda lime was prepared by spraying 100 ml distilled water onto 1 kg fresh soda lime, and water was added only when a new bag of soda lime was placed into the canister. Compound A concentrations in the circle system, soda lime temperatures, inspired and end-tidal CO2 and end-tidal sevoflurane concentrations, and CO2 elimination by the patient were measured during anesthesia. Compound A concentrations were significantly lower for the perhydrated soda lime (1.9 +/...Continue Reading

References

Nov 1, 1975·Anesthesia and Analgesia·R F WallinI J Stern
Apr 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D T Wong, J Lerman
Sep 1, 1995·Anesthesia and Analgesia·L KandelJ Martin
Mar 1, 1994·Anesthesiology·C T GonsowskiR L Kerschmann
Mar 1, 1994·Anesthesiology·C T GonsowskiR L Kerschmann

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Citations

Feb 9, 2000·Pharmacology & Therapeutics·N J O'Keeffe, T E Healy
May 25, 2002·Acta Anaesthesiologica Scandinavica·H H Luttropp, A Johansson
Dec 7, 2013·Case Reports in Medicine·Joshua J LoyaHarminder Singh
Oct 3, 2006·Current Opinion in Anaesthesiology·D H BremerichM Behne
Oct 5, 2006·Current Opinion in Anaesthesiology·A Bedi, J P Howard Fee
Mar 25, 2009·European Journal of Anaesthesiology·Go HirabayashiNagao Ishii
Jun 29, 2001·Anesthesia and Analgesia·H HiguchiT Satoh
Mar 3, 2021·Anesthesia and Analgesia·Shigemasa Ikeda, Hiroshi Makino

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