Effects of the Yuzpe regimen, given during the follicular phase, on ovarian function

Contraception
H B CroxattoA Faundes

Abstract

This study was conducted to assess to what extent the Yuzpe regimen, or half the dose, given in the follicular phase, prevents ovulation during the ensuing 5 days. Sixty women were divided into six groups. All groups received placebo in one cycle and drug in another, in a randomized order. Groups differed by the dose and size of the leading follicle at the time of treatment (12-14, 15-17, or 18-20 mm). Ovulation was absent during the ensuing 5 days in 13 of 20 participants (65%) and in 8 of 20 participants (40%) who received the full and the half dose, respectively, when follicles were 12-17 mm. No ovulation occurred, within the critical period, in 7 of 39 placebo cycles (18%). When follicles were 18-20 mm, treatment did not prevent ovulation. In most drug-treated cycles, plasma gonadotropin and sex steroid levels were significantly depressed within the 5-day period, even when follicular rupture occurred within that period. In conclusion, the Yuzpe regimen can suppress or postpone ovulation to an extent that exceeds the fertile life of spermatozoa. Lack of ovulation within the critical period and dysfunction of the ovulatory process probably account for the contraceptive effect of this method in most cases. The present data do ...Continue Reading

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Citations

Dec 12, 2003·Steroids·Horacio B CroxattoAndrés L Müller
Sep 23, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A FaúndesF Alvarez
Aug 9, 2003·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Sheila DunnUNKNOWN Clinical Practice Gyneacology and Social Sexual Issues Committees, Society of Obstetricians and Gyneacologists of Canada (SO
Aug 13, 2011·Current Opinion in Obstetrics & Gynecology·Kaiyti Duffy, Melanie A Gold
Feb 8, 2008·Annals of Family Medicine·John W CampbellTerrence E Steyer
Feb 20, 2007·Annals of the New York Academy of Sciences·Giuseppe BenagianoManuela Farris
Jan 27, 2010·Pharmacotherapy·Vivian W Y LeungJudith A Soon
Aug 20, 2015·Obstetrics and Gynecology
Feb 20, 2008·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Carlo BastianelliG Benagiano
Sep 10, 2008·Expert Opinion on Pharmacotherapy·Giuseppe BenagianoManuela Farris
Apr 24, 2004·American Journal of Obstetrics and Gynecology·James TrussellTara Shochet
Jan 24, 2014·Clinical Medicine Insights. Reproductive Health·Atsuko KoyamaJudith Linden
Apr 25, 2020·Panminerva Medica·Simona ZaamiAlessandro Del Rio
Sep 9, 2005·Pediatrics·UNKNOWN American Academy of Pediatrics Committee on Adolescence
Nov 28, 2012·Pediatrics·UNKNOWN Committee On Adolescence

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