Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats

Journal of Periodontal Research
Ya-Hsin WuYukihiro Numabe

Abstract

Theaflavins (TFs), the major polyphenol in black tea, have the ability to reduce inflammation and bone resorption. The aim of this study was to evaluate the effects of TFs on experimental periodontitis in rats. Thirty rats were divided into five groups: Control (glycerol application without ligation), Ligature (glycerol application with ligation), TF1 (1 mg/mL TF application with ligation), TF10 (10 mg/mL TF application with ligation), and TF100 (100 mg/mL TF application with ligation). To induce experimental periodontitis, ligatures were placed around maxillary first molars bilaterally. After ligature placement, 100 μL glycerol or TFs were topically applied to the rats daily, and rats were euthanized 7 days after ligature placement. Micro-computed tomography was used to measure bone resorption in the left side of the maxilla, and quantitative polymerase chain reaction was used to measure the expression of interleukin (IL)-6, growth-regulated gene product/cytokine-induced neutrophil chemoattractant (Gro/Cinc-1, rat equivalent of IL-8), matrix metalloproteinase-9 (Mmp-9), receptor activator of nuclear factor-kappa Β ligand (Rankl), osteoprotegerin (Opg), and the Rankl/Opg ratio in gingival tissue. With tissue from the right side...Continue Reading

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Citations

Feb 6, 2020·Experimental and Therapeutic Medicine·Masahiro Ohtani, Tsubasa Nishimura
Oct 10, 2019·Tissue Engineering. Part B, Reviews·Bing WangFang Yang
Feb 16, 2021·Frontiers in Physiology·Scott EpsleyChamith S Rajapakse
Nov 22, 2020·International Journal of Molecular Sciences·Tae-Young KimJae-Young Kim
Dec 15, 2020·Journal of Periodontal Research·Ryutaro KurajiYukihiro Numabe
Sep 6, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Danqi YaoXiao Zhu
Apr 18, 2021·Journal of Oral Biosciences·Saminathan ShadisvaaranXin-Fang Leong
Oct 27, 2021·Journal of Medicinal Food·Yasufumi KatanasakaTatsuya Morimoto

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Methods Mentioned

BETA
biopsies

Software Mentioned

TRI
3D
‐ BON
StepOnePlus
SPSS
Power

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