Effects of theophylline and ipratropium on cognition in elderly patients with chronic obstructive pulmonary disease

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
J W RamsdellP Ferguson

Abstract

To determine whether chronic therapy with theophylline or ipratropium has an adverse effect on cognition and psychomotor skills in geriatric patients with chronic obstructive pulmonary disease. The study design was a randomized, repeated measures, double-blind, double-dummy, placebo-controlled comparison of theophylline and ipratropium treatments. Ambulatory patients were tested at the Clinical Trials Center of the University of California, San Diego, Medical Center. Ambulatory patients with chronic obstructive pulmonary disease aged 65 years or more with FEV1 less than 60% predicted, FEV1/FVC less than 70%, and post bronchodilator FEV1 less than 70%. Patients received either theophylline or ipratropium for 2 weeks, followed by a 1-week placebo control period, then a 2-week treatment period of the alternative drug therapy. A standard therapy of albuterol MDI, 2 puffs (180 microg) qid was given throughout the study. The main response level was an 11-part battery of psychometric tests. Tests were administered at the end of each treatment period and at the end of the washout period. Covariates were sequence of treatment, pulmonary function tests, age, and baseline psychometric test scores. There was no difference in performance sc...Continue Reading

References

Feb 16, 1978·The New England Journal of Medicine·J D WolfeM Simmons
Sep 24, 1992·The New England Journal of Medicine·S LindgrenR Frasher
Apr 1, 1990·Journal of Clinical Pharmacology·M H ChandlerR A Blouin
Nov 1, 1989·The Journal of Pediatrics·T L Creer, K E Gustafson
Sep 1, 1989·The American Review of Respiratory Disease·M FeinleibF M Chevarley
Mar 1, 1989·American Journal of Diseases of Children·L RappaportF Twarog
Jan 1, 1988·The Journal of Allergy and Clinical Immunology·C T FurukawaC W Bierman
Jul 1, 1985·The Journal of Allergy and Clinical Immunology·C SpringerS Godfrey
Oct 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·D Gronwall, P Wrightson
Sep 23, 1993·The New England Journal of Medicine·R Matz
Jan 1, 1993·Chest·J KaplanP C O'Brien
Apr 8, 1993·The New England Journal of Medicine·G T Ferguson, R M Cherniack

❮ Previous
Next ❯

Citations

Oct 12, 2010·Journal of the American Geriatrics Society·Nalaka S GooneratneAmy Corcoran
Aug 6, 2014·International Journal of Geriatric Psychiatry·Delia Bishara, Daniel Harwood
Aug 23, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S A Quadrelli, A Roncoroni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.