Effects of thermal endometrial ablation. Clinicopathologic correlations

American Journal of Clinical Pathology
J R DavisD D King

Abstract

Electrothermal ablation of endometrium was performed on 207 women for abnormal and sometimes painful uterine bleeding. Recurrence of symptoms or inadequacy of treatment led to hysterectomy in 33 women at intervals of 2 weeks to 60 months. Patterns of uterine tissue destruction, healing and repair, and endometrial regeneration were correlated with the postablation interval. The endometrial thickness was completely destroyed. Necrosis dominated the first month, and a chronic repair-regeneration phase followed. Foreign body giant cells reacted with necrotic eschar, remnants of which were present to 47 months. Intact endometrium regenerated focally in 10 uteri and diffusely in 5. Indications for hysterectomy were attributed directly to ablation failure in 18 of 33 cases. Familiarity with the morphologic effects of ablation will aid in relating ablation failures to direct mechanisms, complications of the procedure, or unrelated events.

Citations

Dec 13, 2006·Gynecologic and Obstetric Investigation·Ofer GemerEyal Anteby
Mar 16, 2018·Abdominal Radiology·Monica R DrylewiczCary Lynn Siegel
Mar 12, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Rochelle A SimonC James Sung
Jun 8, 1999·Human Reproduction·F TresserraR Labastida
Sep 24, 2015·AJR. American Journal of Roentgenology·Christopher A DaubKeyanoosh Hosseinzadeh
Jul 1, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Paul Kelly, W Glenn McCluggage

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