Effects of Thermal Preconditioning on Tissue Susceptibility to Histotripsy

Ultrasound in Medicine & Biology
E VlaisavljevichCharles A Cain

Abstract

Histotripsy is a non-invasive ablation method that mechanically fractionates tissue by controlling acoustic cavitation. Previous work has revealed that tissue mechanical properties play a significant role in the histotripsy process, with stiffer tissues being more resistant to histotripsy-induced tissue damage. In this study, we propose a thermal pretreatment strategy to precondition tissues before histotripsy. We hypothesize that a thermal pretreatment can be used to alter tissue stiffness by modulating collagen composition, thus changing tissue susceptibility to histotripsy. More specifically, we hypothesize that tissues will soften and become more susceptible to histotripsy when preheated at ∼60°C because of collagen denaturation, but that tissues will rapidly stiffen and become less susceptible to histotripsy when preheated at ∼90°C because of collagen contraction. To test this hypothesis, a controlled temperature water bath was used to heat various ex vivo bovine tissues (tongue, artery, liver, kidney medulla, tendon and urethra). After heating, the Young's modulus of each tissue sample was measured using a tissue elastometer, and changes in tissue composition (i.e., collagen structure/density) were analyzed histologically...Continue Reading

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Citations

Dec 5, 2018·Physics in Medicine and Biology·Yak-Nam WangVera A Khokhlova
Jun 18, 2021·Frontiers in Oncology·Alissa Hendricks-WengerIrving Coy Allen
Aug 8, 2021·Ultrasound in Medicine & Biology·Sara B KellerMichalakis A Averkiou

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