Effects of thiazide-type and thiazide-like diuretics on cardiovascular events and mortality: systematic review and meta-analysis

Hypertension
Rik H G Olde EngberinkBert-Jan H van den Born

Abstract

Thiazide diuretics are recommended as first-line therapy for hypertension and are among the most commonly prescribed drugs worldwide. According to their molecular structure, thiazide diuretics can be divided in thiazide-type (TT) and thiazide-like (TL) diuretics. TL diuretics have a longer elimination half-life compared with TT diuretics and have been shown to exert additional pharmacological effects, which may differently affect cardiovascular risk. In this meta-analysis, we compared the effects of TT and TL diuretics on cardiovascular events and mortality. Randomized, controlled studies in adult hypertensive patients that compared TT or TL diuretics with placebo or antihypertensive drugs and had ≥1 year follow-up were included. Primary outcome was cardiovascular events; secondary outcomes included coronary events, heart failure, cerebrovascular events, and all-cause mortality. Meta-regression analysis was used to identify confounders and correct for the achieved blood pressure reductions. Twenty-one studies with >480 000 patient-years were included. Outcomes were not affected by heterogeneity in age, sex, and ethnicity among included studies, whereas larger blood pressure reductions were significantly associated with increase...Continue Reading

References

Jan 1, 1981·Japanese Heart Journal·K KuramotoM Murakami
Jan 1, 1993·Journal of Cardiovascular Pharmacology·F RenduD Guez
Oct 26, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·I KuwajimaUNKNOWN National Intervention Cooperative Study in Elderly Hypertensives (NICS-EH) Study Group
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Feb 14, 2003·The New England Journal of Medicine·Lindon M H WingUNKNOWN Second Australian National Blood Pressure Study Group
Jul 24, 2003·Blood Pressure·Ettore MalaccoUNKNOWN Shell Investigators
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 31, 2005·American Journal of Hypertension·Javier Daniel FinkielmanStephen T Turner
Apr 2, 2008·The New England Journal of Medicine·Nigel S BeckettUNKNOWN HYVET Study Group
Dec 5, 2008·The New England Journal of Medicine·Kenneth JamersonUNKNOWN ACCOMPLISH Trial Investigators
Dec 3, 2010·The Journal of Clinical Hypertension·Michael E Ernst, Brian C Lund
Jan 29, 2011·Journal of the American College of Cardiology·Franz H MesserliSripal Bangalore
May 9, 2014·The American Journal of Medicine·Jan C van BlijderveenKatia M Verhamme

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Citations

Apr 7, 2016·American Journal of Hypertension·George C Roush, Domenic A Sica
Aug 1, 2015·Cardiovascular Drugs and Therapy·Amanda J Stolarz, Nancy J Rusch
Jul 4, 2016·Annals of Global Health·James P SheppardRichard J McManus
Sep 2, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ai IbarakiTakuya Tsuchihashi
Nov 30, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Branko BraamS Susan Hedayati
Feb 6, 2018·Current Diabetes Reports·André J Scheen
Feb 5, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Annabella Braschi
Apr 14, 2019·The Journal of Clinical Hypertension·Manfred Stapff, Sarah Hilderbrand
Mar 19, 2019·Journal of Hypertension·Michel BurnierBryan Williams
Jun 21, 2017·Journal of Cellular and Molecular Medicine·Wenjing LiangJingjing Yang
Nov 2, 2017·Oxidative Medicine and Cellular Longevity·M JakubowskiA Doroszko
Oct 5, 2018·JAMA Internal Medicine·Bert-Jan H van den BornLiffert Vogt
Jun 12, 2016·Diabetes Care·Ele FerranniniEric Mayoux
Dec 22, 2017·The Journal of Clinical Hypertension·Kaberi DasguptaNadia Khan
Aug 31, 2018·European Heart Journal·Bryan WilliamsUNKNOWN ESC Scientific Document Group
Dec 4, 2019·Wiener klinische Wochenschrift·Thomas WeberUNKNOWN Österreichische Gesellschaft für Kinder- und Jugendheilkunde
Jan 11, 2018·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Sarah A LambRoss T Tsuyuki
Sep 24, 2019·Frontiers in Pharmacology·Robert M Rapoport, Manoocher Soleimani
Jul 28, 2018·BioMed Research International·Maciej JakubowskiAdrian Doroszko
Mar 19, 2019·The New England Journal of Medicine·Dike B OjjiUNKNOWN CREOLE Study Investigators
Sep 25, 2020·Journal of General Internal Medicine·Michael E JohansenJeremey B Sussman
Aug 4, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi UmemuraNobuhito Hirawa
Jan 4, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Emilio Antonio FrancischettiEvandro Silva Freire Coutinho
Jan 14, 2021·Journal of Human Hypertension·Hussam Al GhoraniFelix Mahfoud
Jan 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Kiwan KangInsoo Jang
May 1, 2021·Current Opinion in Cardiology·Michael F MendozaCarl J Lavie
May 17, 2021·Pharmacology & Therapeutics·Juan TamargoEva Delpón
Oct 5, 2021·Der Internist·Vedat SchwengerAndrew Remppis
Jan 26, 2020·The Lancet Global Health·Thomas LungAnushka Patel

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