Oct 31, 1975

Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives

Y NakazawaH Tachibana


The effects of new thienodiazepine derivatives, such as clotiazepam and Y-7131, on normal human sleep were investigated on 5 subjects and compared to those of benzodiazepine derivatives, such as diazepam and nitrazepam. REM sleep was significantly decreased only with 2 mg of Y-7131 and rebound elevation of REM sleep did not follow in recovery 1 and 2 nights. By using partial differential REM deprivation which was designed by us, there was also no rebound elevation of REM sleep noted in recovery 2 nights following 2 mg of Y-7131 medication. REM sleep was not suppressed with 15 mg of clotiazepam, 6 mg of diazepam and 10 mg of nitrazepam when compared to the baseline night. With regard to NREM sleep, stage 2 was significantly increased with 15 mg of clotiazepam and 10 mg of nitrazepam, but stage SWS was significantly decreased with 10 mg of nitrazepam.

  • References13
  • Citations3


  • References13
  • Citations3


Mentioned in this Paper

Y 7131
Insufficient Sleep Syndrome
Sleep, Slow-Wave
Anti-Anxiety Effect
Benzodiazepine derivative antiepileptics
Benzodiazepine derivative anxiolytics

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