Effects of thiopental on bispectral index and heart rate variability

European Journal of Anaesthesiology
S TsuchiyaAkiyoshi Namiki

Abstract

Thiopental has been reported to reduce sympathetic tone, however, it is not clear whether change in heart rate variability is associated with depth of anaesthesia. The purpose of the present study was to evaluate changes in heart rate variability at different depths of hypnosis during induction of anaesthesia with thiopental. We studied 17 ASA I patients scheduled for minor surgery. The depth of hypnosis was monitored by the BIS. Spectral analysis of heart rate variability using a maximum entropy method resulted in a characteristic power spectrum with two main regions, a high frequency and a low frequency. Haemodynamics, entropy, low frequency, high frequency and low frequency/high frequency were monitored in an awake state and after the induction of anaesthesia. Heart rate increased in a BIS-dependent manner, whereas blood pressure showed no significant changes during the study period. High frequency, entropy and low frequency decreased with a reduction in the BIS value. Low frequency/high frequency showed no significant change during the study period. Induction of anaesthesia with thiopental increased heart rate and decreased high frequency, entropy and low frequency in a BIS-dependent manner, indicating that thiopental reduc...Continue Reading

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Citations

Jun 22, 2012·Journal of Anesthesia·Naoyuki HirataMichiaki Yamakage
Jun 11, 2011·Acta Anaesthesiologica Scandinavica·Anna Teresa MazzeoL B Santamaria
Jul 5, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takafumi NakanoHidetoshi Kamimura
Aug 24, 2019·Frontiers in Physiology·Vânia OliveiraSudhin Thayyil
Nov 23, 2016·Journal of Clinical Anesthesia·Eun-Hee KimMyung-Hee Kim

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