PMID: 6168836May 1, 1981Paper

Effects of thiopental on tension development, action potential, and exchange of calcium and potassium in rabbit ventricular myocardium

Journal of Cardiovascular Pharmacology
W S Frankl, P A Poole-Wilson

Abstract

Thiopental in concentrations of 28 and 227 mumoles/liter reduced the tension developed by isolated rabbit ventricular myocardium by 50 and 80%, respectively. The effect was rapid, reversible, and independent of heart rate. Thiopental (227 mumoles/liter) inhibited influx and efflux of potassium to the same extent, so that no net gain or loss occurred. Calcium influx and efflux were also reduced, but calcium was not displaced from the myocardium in association with the decline of tension. The maximum rate of depolarization of the action potential and the time to 50% repolarization were decreased, but resting membrane potential, amplitude, and time to 90% depolarization were unchanged. The negative inotropic effect of thiopental appears to be due to reduced availability of calcium to the myofibrils.

Citations

Oct 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·L J Weiss-Bloom, D L Reich
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pál PacherCsaba Szabó
Sep 29, 2001·British Journal of Anaesthesia·A Descorps-DeclèreY Lecarpentier
Oct 1, 1984·The Journal of Surgical Research·M A LevisonD D Trunkey
Oct 12, 2005·Journal of Pharmacological Sciences·Hideki SuzukiJunko Kimura
Oct 1, 1989·Circulation Research·R A HaworthH A Berkoff
Mar 23, 2002·International Anesthesiology Clinics·Samir Patel
Feb 1, 1997·Alcoholism, Clinical and Experimental Research·M M el-Mas, A A Abdel-Rahman
Aug 5, 2011·Anesthesia and Analgesia·Robina MatyalFeroze Mahmood
Jul 1, 1996·Anesthesiology·E W HansonC Lynch
Jan 1, 1993·Heart and Vessels·D S SnyderW C Hunter

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