PMID: 6414002Jan 1, 1983Paper

Effects of THIP on chronic anxiety

Psychopharmacology
R Hoehn-Saric

Abstract

The effects of THIP, a GABA agonist, were examined in patients with anxiety disorders. Eight patients were prescribed THIP (5-20 mg) to be taken three times a day for 2 weeks in a single-blind study, with placebo conditions preceding and following the active drug period. Anxiety ratings significantly decreased on several measures during active drug treatment and increased again with placebo administration. However, the anxiolytic effects of THIP appeared to be weak and occurred at, or close to dose levels which induced sedation and undesirable side effects. As with other GABA agonists and GABA-mimetic drugs, side effects included giddiness, depersonalization, poor concentration, and transitory delirious states, suggesting that excessive stimulation of the GABAergic system may disrupt normal brain functioning.

References

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Citations

Oct 1, 1992·Journal of Psychiatric Research·E Costa
Apr 22, 1985·Life Sciences·D J Sanger
Dec 7, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrea L Malizia
Oct 31, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Rainer RupprechtHans-Jürgen Möller
Dec 7, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Povl Krogsgaard-LarsenTommy Liljefors
Jan 12, 2010·Neuroscience and Biobehavioral Reviews·Suat Ying Tan CherlynKang Sim
Feb 9, 2007·Colloids and Surfaces. B, Biointerfaces·Hong-Xing CaoJun-Hong Liu
Feb 19, 2003·Human Psychopharmacology·Rita M CondrenJogin H Thakore
Jan 1, 1988·Medicinal Research Reviews·P Krogsgaard-Larsen
Jul 6, 2005·Pharmacology & Therapeutics·Esa R Korpi, Saku T Sinkkonen
Sep 29, 2004·Biochemical Pharmacology·Povl Krogsgaard-LarsenBjarke Ebert
Aug 17, 2014·Neuropharmacology·Paul D WhissellBeverley A Orser
May 12, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Geraldine S ElflineRaymond M Quock
Jun 19, 2001·American Journal of Physiology. Endocrinology and Metabolism·M LancelS Mathias

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