PMID: 8969399Dec 1, 1996Paper

Effects of thoracic epidural anesthesia on changes in ischemic myocardial metabolism induced by intracoronary injection of endothelin in dogs

Journal of Cardiothoracic and Vascular Anesthesia
S FujitaK Ichihara

Abstract

Thoracic epidural anesthesia (TEA) has been reported to alleviate ischemic damage to the myocardium. Endothelin, an endothelium-derived peptide and a potent coronary vasoconstrictor, may contribute to poor cardiac perfusion and ischemia. The objective was to examine regional myocardial metabolism during ischemia caused by intracoronary injection of endothelin with and without TEA. The three experimental groups and three treatments were randomized. All studies were conducted in a university research laboratory. Thirty anesthetized dogs comprised the study groups. Study animals were divided into three groups of 10 animals each identified as normal saline (NS); TEA; and TEA + blood pressure controlled (TEA + BPC). The NS group had 0.5 mL/kg of normal saline injected into the T4-5 epidural space. The TEA group had 0.5 mL/kg of saline containing 1% lidocaine injected into the T4-5 space. The TEA + BPC group had blood pressure and heart rate maintained at pre-epidural injection values by partially occluding the descending aorta and by atrial pacing. Endothelin (15 pmol/kg) was bolus injected into the left anterior descending (LAD) artery of each heart. Systolic and diastolic blood pressure, heart rate, and LAD coronary blood flow (CB...Continue Reading

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Citations

Mar 1, 2005·Seminars in Cardiothoracic and Vascular Anesthesia·George DjaianiW Scott Beattie
Feb 18, 2006·Nature Reviews. Genetics·Haibin Wang, Sudhansu K Dey

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