PMID: 517049Nov 1, 1979Paper

Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis

Acta Endocrinologica
H SuzukiS Nakagawa

Abstract

The effects of repeated doses of oral cholecystographic agents on serum thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) and thyrotrophin (TSH) concentrations were studied in 37 euthyroid male subjects. Iobenzamic acid, tyropanoic acid, iopanoic acid, and ipodate sodium, in a dosage of 3 g for 3 days, respectively, induced a significant decrease in serum T3 and an increase in rT3 within 24 h after the initial dose, followed by an increase in TSH and a slight increase in T4. The extent of the changes in rT3 varied between the agents, ipodate causing the greatest change, but without any relation to the changes in T3 or T4. Responses of serum T4, T3, rT3 and TSH concentrations to exogenous thyrotrophin-releasing hormone (TRH) and bovine TSH were also studied before and after 3-day doses of iopanoic acid. In 11 subjects given iopanoic acid, the response to TSH to TRH (500 micrograms, iv) was increased but the T3 response was unchanged. A dose of TSH (10 U.S.P. units, im) caused a significant increase in serum T3 and a decrease in TSH concentrations in 5 subjects both before and after cholecystography. It is thus suggested that in euthyroid subjects given multiple doses of oral cholecystographic agents, (...Continue Reading

Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·P H Davies, J A Franklyn
May 1, 1990·Toxicology and Applied Pharmacology·A S JenningsR J Witorsch
Apr 1, 1982·Australian and New Zealand Journal of Medicine·A N HunterJ R Stockigt
Jul 10, 2001·Thyroid : Official Journal of the American Thyroid Association·J C FontanillaD H Sarne
Jan 1, 1985·Langenbecks Archiv für Chirurgie·H DralleR D Hesch
Jan 1, 1982·Catheterization and Cardiovascular Diagnosis·R E KleinmannL E Braverman
Aug 8, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nicole M TyerDorothy S Martinez
Apr 23, 2020·Environmental Science & Technology·Evelyn StinckensDries Knapen

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