Abstract
Properties of thyme extracts from three different species (Thymus vulgaris, Thymus zygis, and Thymus hyemalis) were examined. Two oil fractions from each species were obtained by CO(2) supercritical fluid extraction. Main compounds presented in the supercritical extracts of the three thyme varieties were 1,8 cineole, thymol, camphor, borneol, and carvacrol. As a cellular model of inflammation/atherogenesis, we use human macrophages derived from THP-1 monocytes and activated by oxidized LDLs. These cells were incubated with the thyme fraction oils, and the productions and gene expressions of the inflammatory mediators TNF-α, IL-1B, IL-6, and IL-10 were determined. Thyme extracts significantly reduced production and gene expression of the proinflammatory mediators TNF-α, IL-1B, and IL-6 and highly increased these parameters on the anti-inflammatory IL-10 cytokine. Changes on production and gene expressions were dose dependent and according to the thyme content of each species. Taken together, these results may suggest that thyme extracts could have anti-inflammatory effects.
References
Sep 1, 1992·Dental Materials : Official Publication of the Academy of Dental Materials·S Fujisawa, Y Kadoma
Feb 1, 1992·Atherosclerosis·U IkedaK Shimada
Dec 1, 1988·Inflammation·Y Suzuki, H Furuta
Feb 25, 1983·Pharmaceutisch Weekblad. Scientific Edition·C O Van Den Broucke, J A Lemli
Jan 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R AeschbachO I Aruoma
Jul 1, 1994·Pharmaceutica acta Helvetiae·N DidryM Pinkas
May 1, 1996·The Journal of Clinical Investigation·K UyemuraR L Modlin
Jan 14, 1999·The New England Journal of Medicine·R Ross
Aug 18, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J BergD Stimmeder
Jun 6, 2000·Journal of Ethnopharmacology·T Essawi, M Srour
Jul 3, 2002·Journal of Pharmaceutical and Biomedical Analysis·Mohammad HudaibVanni Cavrini
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K M Soliman, R I Badeaa
Sep 25, 2003·Physiological Reviews·Bjarne Osterud, Eirik Bjorklid
Dec 4, 2003·Biological & Pharmaceutical Bulletin·Mehmet Hakki AlmaToshifumi Hirata
Mar 10, 2004·The Journal of Pharmacy and Pharmacology·E VigoR Perez-Fernandez
Apr 6, 2004·Rheumatic Diseases Clinics of North America·William P Arend, Cem Gabay
May 20, 2004·The Journal of Antimicrobial Chemotherapy·Claudio Galuppo DinizC Jeffrey Smith
Oct 13, 2004·Pulmonary Pharmacology & Therapeutics·Uwe R JuergensHans Vetter
May 19, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S SosaR Della Loggia
Sep 1, 2005·Journal of Agricultural and Food Chemistry·Louis Kuoping ChaoShang-Tzen Chang
Jun 10, 2006·Pharmacology·Pier Carlo BragaLaura Marabini
Jun 24, 2006·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·M P Martínez-Montiel, M T Muñoz-Yagüe
Sep 27, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·M LevulaT Lehtimäki
Sep 30, 2006·Folia Microbiologica·K HorosováV Kmet
Jan 11, 2007·Letters in Applied Microbiology·M Segvić KlarićS Pepeljnak
Aug 22, 2007·Journal of Agricultural and Food Chemistry·Biljana BozinEmilija Jovin
Feb 22, 2008·Mediators of Inflammation·Alexandra BukovskáJuraj Koppel
May 2, 2008·Archives of Pharmacal Research·Sung Kyu KimMin Won Lee
May 14, 2008·Journal of Agricultural and Food Chemistry·Josip MastelićNorbert Müller
Citations
Oct 1, 2013·Nutrition Research·Marit KolbergRune Blomhoff
Mar 31, 2015·Journal of Immunotoxicology·Nasser GholijaniZahra Amirghofran
Jul 22, 2014·Phytotherapy Research : PTR·Azam Alavinezhad, Mohammad Hossein Boskabady
Sep 5, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Rossella CalòLaura Marabini
Nov 22, 2014·Nursing and Midwifery Studies·Marzieh SodouriMohammadreza Memarzadeh
Jun 9, 2016·BMC Complementary and Alternative Medicine·Mohammad Fallah AzadHolger F R Jentsch
Jul 3, 2016·Chemico-biological Interactions·Marinelli OlivieroNabissi Massimo
Sep 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang ZouPing Wang
May 18, 2018·Critical Reviews in Food Science and Nutrition·Jose M LorenzoFrancisco J Barba
May 23, 2018·Phytotherapy Research : PTR·Bahare SalehiJavad Sharifi-Rad
Jun 7, 2019·Environmental Science and Pollution Research International·Mohamed E El-BoshyRiyad A Almaimani
Apr 10, 2018·Natural Product Research·H M HassanS M A Khalik
Jun 9, 2016·BMC Veterinary Research·Hannah AyrleMichael Walkenhorst
May 30, 2017·Asian Pacific Journal of Tropical Medicine·Samah A El-NewaryE A Omer
Jun 26, 2020·Frontiers in Pharmacology·Jennifer MichelKhairana Husain
May 24, 2017·Environmental Science and Pollution Research International·Fardos A M Hassan, Ashraf Awad
Jun 15, 2020·Archives of Microbiology·Leandro Wagner FigueiraLuciane Dias de Oliveira
Aug 6, 2020·Plants·Gema Nieto
Jul 12, 2017·Frontiers in Pharmacology·Mohamed Fizur Nagoor MeeranShreesh K Ojha
May 25, 2018·Zebrafish·Katherine M PolednikLisa K Felzien
Dec 31, 2019·Sport Sciences for Health·Seyed Morteza TayebiHassane Zouhal
Apr 10, 2019·IET Nanobiotechnology·Maryam GholamiHamed Esmaeil Lashgarian
Nov 4, 2020·Scientific Reports·Mariana RoxoLígia Salgueiro
Jan 1, 2021·Plants·Maria Graça MiguelAna Cristina Figueiredo
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Merat MahmoodiMojtaba Sankian
Mar 13, 2021·Scientific Reports·Mohamed Mohamed SolimanMohammed M M Metwally
May 24, 2021·BMC Complementary Medicine and Therapies·Györgyi HorváthEdina Pandur
Aug 15, 2021·Phytotherapy Research : PTR·Fatemeh Vahdat-LasemiAmirhossein Sahebkar
Aug 13, 2021·Environmental Science and Pollution Research International·Mohammad Reza Khazdair, Mohammad Hossein Boskabady