Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages.

Journal of Obesity
A Ocaña, G Reglero

Abstract

Properties of thyme extracts from three different species (Thymus vulgaris, Thymus zygis, and Thymus hyemalis) were examined. Two oil fractions from each species were obtained by CO(2) supercritical fluid extraction. Main compounds presented in the supercritical extracts of the three thyme varieties were 1,8 cineole, thymol, camphor, borneol, and carvacrol. As a cellular model of inflammation/atherogenesis, we use human macrophages derived from THP-1 monocytes and activated by oxidized LDLs. These cells were incubated with the thyme fraction oils, and the productions and gene expressions of the inflammatory mediators TNF-α, IL-1B, IL-6, and IL-10 were determined. Thyme extracts significantly reduced production and gene expression of the proinflammatory mediators TNF-α, IL-1B, and IL-6 and highly increased these parameters on the anti-inflammatory IL-10 cytokine. Changes on production and gene expressions were dose dependent and according to the thyme content of each species. Taken together, these results may suggest that thyme extracts could have anti-inflammatory effects.

References

Sep 1, 1992·Dental Materials : Official Publication of the Academy of Dental Materials·S Fujisawa, Y Kadoma
Feb 25, 1983·Pharmaceutisch Weekblad. Scientific Edition·C O Van Den Broucke, J A Lemli
Jan 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R AeschbachO I Aruoma
Jul 1, 1994·Pharmaceutica acta Helvetiae·N DidryM Pinkas
May 1, 1996·The Journal of Clinical Investigation·K UyemuraR L Modlin
Jan 14, 1999·The New England Journal of Medicine·R Ross
Aug 18, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J BergD Stimmeder
Jun 6, 2000·Journal of Ethnopharmacology·T Essawi, M Srour
Jul 3, 2002·Journal of Pharmaceutical and Biomedical Analysis·Mohammad HudaibVanni Cavrini
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K M Soliman, R I Badeaa
Sep 25, 2003·Physiological Reviews·Bjarne Osterud, Eirik Bjorklid
Apr 6, 2004·Rheumatic Diseases Clinics of North America·William P Arend, Cem Gabay
May 20, 2004·The Journal of Antimicrobial Chemotherapy·Claudio Galuppo DinizC Jeffrey Smith
Oct 13, 2004·Pulmonary Pharmacology & Therapeutics·Uwe R JuergensHans Vetter
May 19, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S SosaR Della Loggia
Sep 1, 2005·Journal of Agricultural and Food Chemistry·Louis Kuoping ChaoShang-Tzen Chang
Jun 24, 2006·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·M P Martínez-Montiel, M T Muñoz-Yagüe
Sep 27, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·M LevulaT Lehtimäki
Sep 30, 2006·Folia Microbiologica·K HorosováV Kmet
Jan 11, 2007·Letters in Applied Microbiology·M Segvić KlarićS Pepeljnak
Feb 22, 2008·Mediators of Inflammation·Alexandra BukovskáJuraj Koppel
May 14, 2008·Journal of Agricultural and Food Chemistry·Josip MastelićNorbert Müller

❮ Previous
Next ❯

Citations

Jul 22, 2014·Phytotherapy Research : PTR·Azam Alavinezhad, Mohammad Hossein Boskabady
Sep 5, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Rossella CalòLaura Marabini
Nov 22, 2014·Nursing and Midwifery Studies·Marzieh SodouriMohammadreza Memarzadeh
Jun 9, 2016·BMC Complementary and Alternative Medicine·Mohammad Fallah AzadHolger F R Jentsch
May 23, 2018·Phytotherapy Research : PTR·Bahare SalehiJavad Sharifi-Rad
May 30, 2017·Asian Pacific Journal of Tropical Medicine·Samah A El-NewaryE A Omer
May 24, 2017·Environmental Science and Pollution Research International·Fardos A M Hassan, Ashraf Awad
Nov 4, 2020·Scientific Reports·Mariana RoxoLígia Salgueiro
Jan 1, 2021·Plants·Maria Graça MiguelAna Cristina Figueiredo
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Merat MahmoodiMojtaba Sankian
Aug 13, 2021·Environmental Science and Pollution Research International·Mohammad Reza Khazdair, Mohammad Hossein Boskabady

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

GraphPad Prism
GraphPad
GCMS Solution

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
A Ocaña-FuentesG Reglero
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Francesca BraviCarlo La Vecchia
© 2021 Meta ULC. All rights reserved