PMID: 29477139Feb 25, 2018Paper

Effects of Thymol, a Natural Phenolic Compound, on Human Gastric Adenocarcinoma Cells In Vitro

Alternative Therapies in Health and Medicine
Ayse Günes-BayirHuriye Senay Kiziltan

Abstract

Alternative and complementary medicine has gained importance in anticancer treatment, reflecting a movement toward an integrated approach to treating various diseases. Natural products originating from plants can contain biologically active substances. Thymol is a major component of many plants from the family Lamiaceae that are often used for medicinal and culinary purposes in Mediterranean countries. The purpose of the present study was to investigate thymol's cytotoxic, genotoxic, apoptotic effects on gastric adenocarcinoma (AGS) cells, including measurement of reactive oxygen species (ROS) and glutathione (GSH) levels at the same time. The research team studied thymol's anticancer potential in vitro. The research was conducted at the Laboratory of Biochemistry of the Faculty of Medicine at Bezmialem Vakif University (Istanbul, Turkey). Caucasian human AGS cells were exposed to 7 concentrations of thymol-10, 20, 30, 50, 100, 200, and 400 μM-prepared from a stock solution of 600 μM of thymol in dimethyl sulfoxide (DMSO), and after 24 h of incubation, the results were analyzed. The thymol was obtained commercially. The study used a negative control prepared in a concentration of 1:1000 from the stock solution of DMSO. Cytotoxi...Continue Reading

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