PMID: 6978521Jan 1, 1982Paper

Effects of thymosin and evidence of monocyte suppression of both T- and B-cell functions in two cases of 'common variable immunodeficiency'

Scandinavian Journal of Immunology
M P Arala-ChavesH H Fudenberg

Abstract

We have studied two patients with common variable immunodeficiency (CVID), impaired cell-mediated immunity, and high percentages of monocytes in their peripheral blood. Removal of monocytes from cultures of peripheral blood mononuclear cells from both patients increased the in vitro responses to phytohaemagglutinin (PHA) and concanavalin A (Con A) but not to purified protein derivative (PPD), as measured by [3H]thymidine uptake. Similarly, supernatants of monocyte cultures from both patients, unlike supernatants of normal monocytes, suppressed the in vitro responses to PHA and Con A but enhanced the response to PPD by cultured mononuclear cells from the patients and from normal donors. Addition of unfractionated mononuclear cells from both patients to normal mononuclear cells suppressed both pokeweed mitogen (PWM) stimulation and IgG production; this effect was abrogated by removal of monocytes from the patients' mononuclear cell populations. This effect of thymosin on both patients' mononuclear cells was assayed in vitro. Thymosin was ineffective in vitro with cells from the first patient; for the other patient, [3H]thymidine uptake by mononuclear cells stimulated with PPD increased, whereas uptake by Con A-stimulated cells de...Continue Reading

References

May 1, 1976·The Medical Clinics of North America·A L GoldsteinJ T Ulrich
Feb 28, 1975·Annals of the New York Academy of Sciences·G H CohenA L Goldstein
Jul 1, 1976·The Journal of Clinical Investigation·F P SiegalR A Good
Dec 1, 1975·Annals of Internal Medicine·P FriendA F Michael
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J F BachA White
Jan 1, 1971·International Archives of Allergy and Applied Immunology·P C Wilkinson, I C McKay
Nov 1, 1966·The Journal of Experimental Medicine·E F Osserman, D P Lawlor
Oct 1, 1980·Clinical Immunology and Immunopathology·M P Arala-ChavesR Mello-Vieira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.